Synthesis, Characterization, and Antimicrobial Studies of Some Quinolines Containing 1,3-Thiazines

AlCl3‐Catalyzed Synthesis of Triazolo[5,1‐b]thiazines

“…A literature survey discloses that there are few reports for the synthesis of triazolothiazines. Triazole fused with thiazine ring system possess anti‐inflammatory, [4a] cytotoxic, [4b] anti‐tumor, [4c] anti‐bacterial [4d] and anti‐fungal [4e] activities (Figure 1). Peter and co‐workers have reported [5] triazolo[5,1‐ b ]thiazinones in fair to good yield from the reaction of 1,2,4‐triazole‐3‐thiols and diethyl ethoxy‐methylenemalonate.…”

Chemistry of 1,3-thiazin-4-ones and their derivatives, 1995 - mid-2018

“…Reaction of 2-chloroquinoline-3-carboxylic acids 433 with sulfanyltriazoles 434 led to tetracyclic compounds 435 (Scheme 135). 232…”

Synthesis, Characterization, Antimicrobial and Corrosion Inhibition Studies of Fused Oxadiazolo‐quinolines

“…[8,9] Also 1,3,4-oxadiazole derivatives have been found to exhibit diverse biological activities such as antimicrobial, [10,11] anti-HIV, [12] antitubercular, [13] antimalarial, [14] anti-inflammatory, [15,16] anticonvulsant, [17] and antitumor. [18] In an earlier communication, [19] synthesis and antimicrobial studies of 2-(p-substituted aryl)-s-triazolo[5,1-b]-6/8-substituted quinolino [1,3]thiazin-9(H)-ones were reported. Quinoline derivatives carrying 1,2,4-oxadiazole moiety were synthesized and evaluated for antituberculosis studies.…”