Synthesis, characterization and antimicrobial studies of some metal complexes with mixed ligands derived from Mannich bases and diamine ligands

Abstract

The present study deals with the structure and antimicrobial properties of a new series complexes of Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) ions with mixed ligands involved Mannich ligand (L) and diamine ligand (L’). L=Mannich ligands involved L1, L2, L3 namely: L1 = N-[1-Morpholino-(3-methoxy,4-hydroxy)benzyl]acetamide (MBA) L2 = N-[1-Morpholino-(3-methoxy,4-hydroxy)benzyl]Benzamide (MBB) L3 = N-[1-Morpholino-(3-methoxy,4-hydroxy)benzyl]Urea (MBU) L’ Ligand is a 1,10-phenanthroline. These complexes were prepared from the direct reaction of the metal (II) chloride, mannich bases (MBA, MBB, MBU) and diamine ligand namely with mole ration (2:1:1) of L:M:L’ categories of complexes were synthesis is mononuclear complexes of formula: [M(L)2(L’)].nH2O where M = Fe(II), Co(II), Ni(II), Cu(II), Zn(II). L = Mannich base (MBA, MBB, MBU). L’ = 1,10-phenanthroline. The structure of each complex was characterized by spectroscopic methods (IR, UV-Visible), molar conductivity, elemental analysis (C.H.N) and atomic absorption techniques as well as magnetic data. The completion of the reaction checked by using TLC. The mannich bases (L) and diamine ligands coordinated to the metal ion as bidentated ligands through the oxygen atom of the carbonyl group of amide, nitrogen atom of morpholine and two nitrogen atoms of diamine ligand. The following geometrical with all metal ions showed octahedral geometry. Antibacterial activity of the ligand and its complexes was tested against some select bacterial.