Synthesis, Characterization and Antimicrobial Studies of Schiff Base Ligand Derived from Cefadroxil and Benzaldehyde

Abstract

Infectious diseases have been a major health problem for decades in the under developed countries and the emergence of multi drug resistant strains further complicates the situation. In the ongoing quest to discover more effective remedies, several antibiotics have been procured or synthesized. Advanced research into synthetic chemistry has pointed out several organic compounds with antimicrobial potential. Schiff bases are one of such compounds. Cefadroxil is a bactericidal antibiotic. This research aims at discussing the synthesis of a Schiff base out of a fairly common antibiotic cefadroxil and benzaldehyde. This ligand was synthesized and characterized by elemental analysis and some other physico-chemical techniques. This synthesized compound was characterized by different spectroscopic techniques. It was also subjected to melting point determination, TLC (thin layer chromatography), Chemical tests and solubility tests. The Schiff base was screened for antibacterial and antifungal activity in-vitro by disc diffusion method. MIC study for the most susceptible organism was also performed.