Synthesis, Characterization and Antimicrobial Screening of Some Novel 5-(Benzofuran-2-Yl)-N'-(2- Substituted-4-Oxothiazolidin-3-Yl)-1-Phenyl-1hpyrazole-3-Carboxamide Derivatives

Idrees, Mohd.; Kola, S.; Siddiqui, Naqui J.

doi:10.31788/rjc.2019.1245467

Cited by 3 publications

(1 citation statement)

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“…[7][8][9] Majority of the pharmaceutical products are heterocyclic molecules that meet the expectations of biological and industrial requirements. The present study involves the synthesis of high bioactive compounds like benzimidazole, thiazole and pyrazole which exhibit various biological activities like antitumor 10 , analgesic 11 , antimicrobial [12][13] , antibacterial [14][15] and anti-inflammatory etc . 16 Hence, in this direction, efforts have been undertaken to introduce most active and biologically versatile molecules containing nitrogen and sulphur triheterocyclic compounds like Benzo [d] imidazole-2-yl -3, 5 substituted diphenyl -3,3a, 5, 6 -Tetrahydro 2H-pyrazole thiazole derivatives which were synthesized from 2-amino-substituted benzimidazole.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Molecular Docking and Antitubercular Activity of New Bi Heterocyclic Compounds on Benzimidazole Moiety

Kotte¹,

Gullapelli²,

Maroju³

et al. 2020

RJC

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A series of new and efficient Benzo [d] imidazole-2-yl -3, 5 substituted diphenyl -3,3a.5.6 -Tetrahydro 2H-pyrazole thiazole derivatives (4a-j) were synthesized from Schiff base derivatives of thiazolidinediones (3a-j) using hydrazine hydrate. The synthesized compounds were screened for their antitubercular and molecular docking studies. The results of docking studies are supporting antitubercular activity showing high inhibition constant and binding energy. The structures of synthesized compounds were characterized by IR, 1 HNMR, Mass spectroscopic methods.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Molecular Docking and Antitubercular Activity of New Bi Heterocyclic Compounds on Benzimidazole Moiety

Kotte¹,

Gullapelli²,

Maroju³

et al. 2020

RJC

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Benzofuran as a promising scaffold for the synthesis of novel antimicrobial agents

Abbas

Dawood

2022

Expert Opinion on Drug Discovery

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Therapeutic Potential of Naturally Occurring Benzofuran Derivatives and Hybrids of Benzofurans with other Pharmacophores as Antibacterial Agents

Zhou

et al. 2022

CTMC

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: Gram-positive and Gram-negative pathogens are able to evade the host immune system, persist within the human host, and lead to severe disease and even death. At present, bacterial infections are one of the leading causes of morbidity and mortality across the world. Development of novel antibacterial agents still represents a challenging endeavor, which is mainly attributed to the continuous emergence of more virulent and drug-resistant pathogens. Benzofuran constitutes the core of diverse pharmacologically active compounds, and there are a variety of approved benzofuran-based drugs in the market or currently going through different clinical phases or registration statuses. Benzofurans could exert antibacterial activity through various mechanisms and possess pronounced activity, so benzofuran is a useful skeleton for the discovery of novel antibacterial agents. This review focuses on the recent advancement of naturally occurring benzofuran derivatives and hybrids of benzofurans with other pharmacophores as antibacterial agents, covering articles published between January 2015 and July 2021. The chemical structures and structure-activity relationships are also discussed.

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Synthesis, Characterization and Antimicrobial Screening of Some Novel 5-(Benzofuran-2-Yl)-N'-(2- Substituted-4-Oxothiazolidin-3-Yl)-1-Phenyl-1hpyrazole-3-Carboxamide Derivatives

Cited by 3 publications

References 0 publications

Synthesis, Molecular Docking and Antitubercular Activity of New Bi Heterocyclic Compounds on Benzimidazole Moiety

Synthesis, Molecular Docking and Antitubercular Activity of New Bi Heterocyclic Compounds on Benzimidazole Moiety

Benzofuran as a promising scaffold for the synthesis of novel antimicrobial agents

Therapeutic Potential of Naturally Occurring Benzofuran Derivatives and Hybrids of Benzofurans with other Pharmacophores as Antibacterial Agents

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