Synthesis, Characterization and Antimicrobial Properties of Superparamagnetic α-Fe2O3 Nanoparticles Stabilized by Biocompatible Starch

Graphic abstract Increased antimicrobial resistance demands the development of new antimicrobial agents with high potency. A wide variety of microbial systems are continuously subjected to mutations which ultimately results in antimicrobial resistance. The present study aimed at the fabrication of a nano drug delivery system which simultaneously is superparamagnetic, fluorescent, non-cytotoxic and antifungal. The developed system is an easily targetable and detectable tool owing to its superparamagnetic and fluorescent characteristics respectively. Superparamagnetic iron oxide nanoparticles stabilized by macromolecular starch have been incorporated into a fluorescently modified carrier system to get the final drug delivery system. The finally developed drug carrier system is found to be non-cytotoxic from the in vitro cytotoxicity studies performed against normal rat spleen cells. The photodynamic antifungal capability of the system was the premier concern of investigation of the present study. The antifungal studies were conducted against Histoplasma capsulatum and Trichophyton rubrum by well diffusion method and the results were compared with the activity of the antibiotic, griseofulvin. The minimum inhibitory concentration against each fungal strain was determined using broth dilution method. Supplementary Information The online version contains supplementary material available at 10.1007/s10570-021-04107-y.

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“…The zero-valent iron was then air oxidized to Fe 2 O 3 . The detailed synthetic procedure is reported elsewhere (Philip and Kuriakose 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Photodynamic antifungal activity of a superparamagnetic and fluorescent drug carrier system against antibiotic-resistant fungal strains

Philip

Kuriakose

2021

Cellulose

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“…The insurgence of antimicrobial resistance is the greatest promoter of the fabrication of cutting-edge drug delivery systems. Iron oxide nanoparticles have always merited an outstanding place in drug delivery, thanks to their recognized biomedical importance, precise targeting, and biocompatibility [50].…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

“…In a summarized manner, iron oxide nanoparticles (IONPs) were synthesized using macromolecular stabilizing starch, noteworthy for their biocompatibility and agglomeration prevention. Upon encapsulation with starch, a shift in magnetic behavior takes place, converting the once weakly ferromagnetic IONPs into superparamagnetic (SPIONs) [50,51]. The SPIONs were successfully incorporated in a fluorescently modified carrier system, enabling not only an easy identification of the system in a living body but also the application of this system in photodynamic therapy.…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Is Micro and Nanotechnology Helping Us Fight Histoplasmosis?

Filipa¹,

Domingos²,

Salette³

et al. 2023

Infectious Diseases

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Histoplasmosis is an airborne systemic infection, with varied clinical manifestations, from asymptomatic infection to disseminated disease with a deadly outcome. Due to a growing number of immunosuppressed people, this mycosis has become more prevalent and thus, a cause for concern within the medical community. In fact, this fungal infection can be quite serious for children, elderly, people who have had an organ transplant, HIV-positive or people taking immunosuppressants. There has been a limited number of research articles suggesting polymeric, metallic, or lipid micro and nanotechnology-based approaches as a potential way to carry antifungal drugs to treat histoplasmosis. These new drug delivery systems present a variety of means of administration, thereby allowing a more targeted treatment to the lungs, skin, or eyes, according to the infection site. In this review, the aim was to explore these new therapies that have been emerging which hold great potential in comparison to regular antifungal treatments, not only due to their safety but also due to their drug release profile.

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“…The ltered black Fe(0) was air oxidized to reddish brown α-Fe 2 O 3 , at room temperature. The sample was heated at 200 0 C to oxidize all hydroxides if present [7]. The composite corresponding to each capping agent and their representative notations used throughout this paper is denoted in Table 1.…”

Section: Synthesis Of Cyclodextrin/hyperbranchedmentioning

confidence: 99%

“…The study aimed at the thermal stability enhancement of these capping agents on incorporation of iron oxide nanoparticles (IONPs). Stabilized iron oxide nanoparticles often exhibit superparamagnetism [7,29] which can be propagated to be applied in most modern, suave theranostic techniques including hyperthermia, MRI contrasting and so on. Hence the thermal properties of iron oxide nanocomposites are to be studied in detail.…”

Section: Introductionmentioning

confidence: 99%

Effect of iron oxide nanoparticles on the thermal characteristics of supramolecular, dendritic and macromolecular capping agents

Philip¹,

Kuriakose²

2022

Chem. Pap.

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The present study aimed at the enhancement of the thermal characteristics of different capping agents belonging to different macromolecular families, with the incorporation of iron oxide nanoparticles. Iron oxide nanocomposites were prepared following a simple reduction protocol using sodium borohydride (NaBH 4 ) succeeded by air oxidation. Three iron oxide composites were prepared using different biocompatible capping agents. The capping agents used in the present study were supramolecular βcyclodextrin, dendritic hyperbranched polyglycerol and macromolecular starch. The chemical nature of the composites was successfully con rmed by spectroscopy. The well characterized composite systems were studied for their thermal characteristics using TG/DTG and DSC measurements. The primary focus of the study was to analyse any change in the thermal behaviour of the pure encapsulating systems on incorporation with the iron oxide species. The analysis was conducted by comparing the TG/DTG and DSC measurements of the pure capping agents-cyclodextrin, hyperbranched polyglycerol and starch with their respective nanoparticle incorporated composites.

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Synthesis, Characterization and Antimicrobial Properties of Superparamagnetic α-Fe2O3 Nanoparticles Stabilized by Biocompatible Starch

Cited by 7 publications

References 37 publications

Photodynamic antifungal activity of a superparamagnetic and fluorescent drug carrier system against antibiotic-resistant fungal strains

Photodynamic antifungal activity of a superparamagnetic and fluorescent drug carrier system against antibiotic-resistant fungal strains

Is Micro and Nanotechnology Helping Us Fight Histoplasmosis?

Effect of iron oxide nanoparticles on the thermal characteristics of supramolecular, dendritic and macromolecular capping agents

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