SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF Mn(II),Fe(II), Ni(II),Co(II) AND Zn(II) COMPLEXES OF SCHIFF BASE DERIVED FROM 2,2- DIMETHYLPROPANE 1, 3-DIAMINE AND 5-CHLORO ISATIN

Abstract

A new Schiff base Ligand (L)( where L= 3Z,3'Z)-3,3'-((2,2-dimethylpropane-1,3-diyl)bis(azanylyidene))bis(5chloroindolin-2-one) has been synthesized by condensation of 5-Chloroisatin and 2, 2-dimethyl propane-1, 3diamine respectively in the molar ratio of 2:1.The synthesized ligand(L) was used to synthesis metal complexes of transition metals ( Mn(II), Fe(II), Co(II), Ni(II), and Zn(II)). The ligand and its metal complexes have been characterized by elemental analysis, FT-IR, UV-Visible, ESI-Mass spectrometry and 1 H-NMR and 13 C-NMR spectra. On the basis of Spectral data it is revealed that the ligand is N, N, O, O tetradentate and coordinated to the metal ion to both azomethine N atoms and O atoms of lactum group. All the metal complexes show octahedral geometry except Ni(II) and Zn(II) they possess square planar geometry. The ligand and its metal complexes were tested for antibacterial activities. Metal Complexes showed better antibacterial activities as compare to Ligand.

New Tetra-dentate Schiff Base Ligand N2O2 and Its Complexes with Some of Metal Ions: Preparation, Identification, and Studying Their Enzymatic and Biological Activities

“…The ligand spectrum also revealed another new signal at (=5.16 ppm, s, 2H), related to coordinated H 2 O 30 . The 13 C signals of Zn(II) complex did not appear clearly due to poor solubility. The infrared bands assignments of ligand and its metallic complexes have been listed in Table 2.…”

“…2. 13 C NMR spectrum of (H 3 L), Fig. 3, showed significant signals at (=166.4) ppm, (=163.0 ppm, and (= 159.2) ppm, assigned to carboxylic (C=O), phenolic (C-O), and azomethinic (C=N) carbons 6 .…”

“…The poly or tetra-dentate Schiff base ligands with N 2 O 2 coordination system and their metallic complexes have been also gained the attention of scientific researchers due to excellent complexation ability, so it is used in analytical field to remove of some heavy pollutant metals (such as Hg(II) and Ag(I)) from liquid media, in selective separation and purification of Cu(II) ions from mixtures, used as optical sensors for the determination of copper ion, and used as modified electrodes sensor of the aliphatic alcohols [7][8][9][10][11] . In biological fields, the complexes of N 2 O 2 Schiff base ligands were used as anti-bacterial against gram negative and gram-positive types, antifungal, anticancer, antioxidant, as enzyme inhibitors, antiinflammatory, and DNA-cleavage in presence of hydrogen peroxide [12][13][14][15][16][17][18][19][20] . In catalytic reactions the tetra-dentate Schiff base ligands have been used for controlling the radical polymerization, as catalysts for oxidation of phenol, a good catalytic for increasing the chain length of the imine compartment, used as active catalyst for Suzuki and Heck reactions of Iodobenzene, used to catalyze the aerobic oxidation of catechol derivative, and used as catalyst for conversing of Naphthalene derivative to derivative of Naphthoquinone (K 3 vitamin), in green synthesis process [21][22][23][24][25][26] .…”

Iron–Imine Cocktail in Drug Development: A Contemporary Update

“…The complex showed better antibacterial activity against the selected bacterial and fungal strains than the Schiff base ligand. The complex showed the highest activity against A. niger (16 mm) and low activity against E. coli fungal strains (15 mm) (Table 2) [60]. The improved activity of the complexes in relation to their ligands can be explained based on Overtone's concept and Tweedy's chelation theory [46,56].…”

Iron-Imine Cocktail in Drug Development: A Contemporary Update

“…The complex showed better antibacterial activity against the selected bacterial and fungal strains than the Schiff base ligand. The complex showed the highest activity against A. niger (16 mm) and low activity against E. coli fungal strains (15 mm) (Table 2) [60]. The improved activity of the complexes in relation to their ligands can be explained based on Overtone's concept and Tweedy's chelation theory [46,56].…”