Synthesis, characterization and antimicrobial activity of benzo thiazoles and 1,3 oxazine based derivatives of s-triazine

Abstract

In the present study, some new substituted 1,3,5 triazine derivatives with 4- (benzo[d]thiazol-2-yl)aniline and 6-(4-methoxyphenyl)-4-phenyl-2H-1,3-oxazin-2-amine and primary amine were synthesized and evaluated for their in vitro antimicrobial activity against Gram positive and Gram negative strains using a micro dilution procedure. Synthesized compounds P1DH to P15DH prove to be effective with MIC (µg/mL), among them P3DH, P4DH, P5DH, P15DH and P9DH showed excellent activity against a panel of microorganisms. The newly synthesized compounds were characterized using IR, 1 H-NMR, 13 CNMR, MASS Analysis.