Synthesis, characterization and antimicrobial activity of thiazole, benzothiazole and pyrimidine derivatives bearing sydnone moieties

Asundaria, Shahrukh T.; Patel, Keshav C.

doi:10.1007/s11094-012-0712-5

Cited by 15 publications

(7 citation statements)

References 12 publications

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“…Thus the discovery of novel and potent antibacterial as well as antifungal agent is more demanding and challenging for chemists and pharmacists nowadays. Sahu et al [14] thiazole, benzothiazole (16), and pyrimidine heterocycles is described by Asundaria and Patel [16] Figure 3).…”

Section: Antimicrobial Activity the Design Of New Compoundsmentioning

confidence: 97%

Biological Aspects of Emerging Benzothiazoles: A Short Review

Ali

Siddiqui

2013

Journal of Chemistry

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In recent years heterocyclic compounds analogues and derivatives have attracted wide attention due to their useful biological and pharmacological properties. Benzothiazole is among the usually occurring heterocyclic nuclei in many marine as well as natural plant products. Benzothiazole is a privileged bicyclic ring system with multiple applications. It is known to exhibit a wide range of biological properties including anticancer, antimicrobial, and antidiabetic, anticonvulsant, anti-inflammatory, antiviral, antitubercular activities. A large number of therapeutic agents are synthesized with the help of benzothiazole nucleus. During recent years there have been some interesting developments in the biological activities of benzothiazole derivatives. These compounds have special significance in the field of medicinal chemistry due to their remarkable pharmacological potentialities. This review is mainly an attempt to present the research work reported in the recent scientific literature on different biological activities of benzothiazole compounds.

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Section: Antimicrobial Activity the Design Of New Compoundsmentioning

confidence: 97%

Biological Aspects of Emerging Benzothiazoles: A Short Review

Ali

Siddiqui

2013

Journal of Chemistry

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“…The required chalcones were synthesized by aldol condensation 19 of aryl aldehydes with acetophenone derivatives in the presence of KOH, and the 4-aryl-1H-1,2,3-triazoles were prepared from the corresponding nitrostyrene derivatives. 20 In our initial studies, we examined the reaction of the chalcone 1a and 4-(4-methoxyphenyl)-1H-1,2,3triazole (2b) in acetonitrile at 0 °C in the presence of DABCO (40 mol%).…”

Section: Syn Lettmentioning

confidence: 99%

“…Under these conditions, the use of DMAP did not result in any improvement (entry 15). At this stage, the aza-Michael reaction between 1a and 2b was carried out with one equivalent of DABCO in a mixture of acetonitrile and methanol at 85 °C for three days (entries [16][17][18][19][20]. We found that an increased amount of methanol resulted in a decreased yield of product 3j.…”

Section: Syn Lettmentioning

confidence: 99%

Regiospecific Aza-Michael Addition of 4-Aryl-1H-1,2,3-triazoles to Chalcones: Synthesis of 2,4-Disubstituted 1,2,3-Triazoles in Basic Medium

Bhagat

Peddinti

2017

Synlett

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A novel metal-free and base-mediated method to display the donor ability of 1,2,3-triazoles for the synthesis of 2,4-disubstituted 1,2,3-triazoles has been developed. A DABCO-promoted aza-Michael addition of 4-aryl NH-1,2,3-triazoles to α,β-unsaturated ketones (chalcones) is presented. The reactions proceeded with complete regiospecificity in a 3:1 mixture of acetonitrile and methanol at 85 °C to provide 2,4-disubstituted 1,2,3-triazoles as Michael adducts, and the addition products 1,3-diaryl-(4-aryl-2H-1,2,3-triazol-2-yl)propan-1-ones were isolated in high yields.

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“…Benzimidazoles are widely used group in the pharmaceutical industry because 5,6-dimethylbenzimidazole is a component of vitamin B12. Benzimidazole derivatives exhibits a wide range of biological properties including antimicrobial, antibacterial, antitumor, anticancer, anti-inflammatory and analgesic activities [1][2][3][4][5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Study of New Benzimidazole Schiff Bases Bearing P-Toluene Sulfonamide Moiety

Tunç

2019

J. Chil. Chem. Soc.

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Three new Schiff bases bearing benzimidazole and p-toluen sulfonamide moiety were synthesized. Their structures were characterized by elemental analysis, FTIR, NMR and LCMS methods. The antimicrobial properties of the compounds were also evaluated. All compounds exhibit higher antimicrobial activity against all bacteria, Schiff bases (4a-4c) shows more activity than the parent aldehyde (3). 4c displays higher antibacterial activity against P. aeruginosa compare to reference drug Sulfioxazole. The compounds were found more potent against Gram-negative than Gram positive bacteria. One more free phenyl group increase the activity in 4c, but one more phenyl ring in 4b does not.In vitro antifungal activity of the compounds was also tested on fungi C. albicans C. tropicalis and C. krusei. However, our compounds exhibit no antifungal activity against three fungi.

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Synthesis, characterization and antimicrobial activity of thiazole, benzothiazole and pyrimidine derivatives bearing sydnone moieties

Cited by 15 publications

References 12 publications

Biological Aspects of Emerging Benzothiazoles: A Short Review

Biological Aspects of Emerging Benzothiazoles: A Short Review

Regiospecific Aza-Michael Addition of 4-Aryl-1H-1,2,3-triazoles to Chalcones: Synthesis of 2,4-Disubstituted 1,2,3-Triazoles in Basic Medium

Synthesis and Antimicrobial Study of New Benzimidazole Schiff Bases Bearing P-Toluene Sulfonamide Moiety

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