Synthesis, Characterization and Antimicrobial Activity of a New Aromatic Sulfonyl Hydrazone Derivative and Its Transition Metal Complexes

Abstract

In this study, benzenesulfonicacid‐1‐methylhydrazide (bsmh) derivatives such as 2‐hydroxy‐1‐naphtaldehydebenzenesulfonylhydrazone (Hnafbsmh) and its Ni(II), Pd(II), Pt(II), Cu(II), Co(II) complexes were synthesized. The structures of these complexes were investigated using elemental analyses (FT‐IR, LC‐MS, UV‐VIS), magnetic susceptibility and conductivity measurement techniques. The complexes were found to have general compositions [ML2]. All the synthesized complexes were evaluated in vitro as antimicrobial agents against representative strains of six gram‐positive and four gram‐negative bacteria and as an antifungal agent by disc diffusion methods. All the bacteria and fungi studied were screened against some commercial antibiotics to compare them with our chemical's zone diameters.

Development and Validation of HPLC-DAD and UHPLC-DAD Methods for the Simultaneous Determination of Guanylhydrazone Derivatives Employing a Factorial Design

“…Guanylhydrazones are widely studied molecules of great scientific interest due to their broad biological potential, which includes antihypertensive, antidiabetic, antimalarial, trypanocidal, anti-bacterial and antitumoral activities [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. Andreani et al synthesized and evaluated the biological activity of some new guanylhydrazones against a series of lung, breast and glioma tumors.…”