Synthesis, Characterization and Antimicrobial Activity of Some Organotin (IV) Complexes with a Potassium Hydrogen Ethanedioate Ligand

Abstract

Four series of organotin (IV) derivatives of potassium hydrogen ethanedioate: Bu 2 SnL 2, Bu 3 SnL, Ph 2 SnL 2 and Ph 3 SnL have been synthesized characterized by tin content analysis, FTIR, 1 H NMR and 13 C NMR and tested for antimicrobial activity against four Gram-positive bacteria: Staphylococcus aureus, Streptococcus pyogenes, Bacillus cereus, Corynebacterium ulcerans, four Gramnegative Bacteria: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas aeruginosa and four fungi strains of Microsporum spp:Microsporum audounii, Microsporum distortum, Microsporum gallinae and Microsporum gypseum. Result showed that the compounds synthesized in general exhibited greater antimicrobial activity than potassium hydrogen ethanedioate. Organotin moieties play a vital role in deciding the antimicrobial activity of an organotin compound, this is true in this work. The order for the antifungal activity in this study