Synthesis, Characterization and Antimicrobial Activity of Metal Chelates of 5‐[1(<i>H</i>)‐Benzotriazole methylene]‐8‐quinolinol

Patel, Hasmukh S.; Oza, Kaushal K.

doi:10.1155/2009/243931

Cited by 10 publications

(6 citation statements)

References 4 publications

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“…In the IR spectrum of the CA membrane (Figure 2a), bands characteristic of CA appeared at 1740 cm −1 for the C=O groups, at 1369 and 1226 cm −1 for the CH 3 groups, and at 1037 cm −1 for the ether C–O–C groups, in accordance with the literature [20]. In the FTIR spectra of CA/5-Cl8Q (Figure 2b) membranes, in addition to the characteristic bands of CA, a new band appeared at 1500 cm −1 characteristic of a quinoline ring [21], proving the presence of the bioactive compound in the electrospun membrane. In the spectra of the CA/PEG and CA/PEG/5-Cl8Q, new characteristic bands were observed at 1100 cm −1 , assigned to the C-O-C ether groups of PEG, as well as at 2875 cm −1 characteristic for the vC–H vibrations.…”

Section: Resultssupporting

confidence: 87%

Electrospun 5-chloro-8-hydroxyquinoline-Loaded Cellulose Acetate/Polyethylene Glycol Antifungal Membranes Against Esca

et al. 2019

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Esca is one of the earliest described diseases in grapevines and causes trunk damage and the sudden wilting of the entire plant; it is caused mainly by the species Phaeomoniella chlamydospora (P. chlamydospora) and Phaeoacremonium aleophilum (P. aleophilum). In practice, there are no known curative approaches for fighting esca directly, which is a huge problem for preserving vineyards. Micro- and nanofibrous membranes from cellulose acetate (CA) and cellulose acetate/polyethylene glycol (CA/PEG) containing 5-chloro-8-hydroxyquinolinol (5-Cl8Q) were successfully prepared by electrospinning. The surface morphologies and optical and mechanical properties of the membranes were characterized by using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-Vis), water contact angle measurements and mechanical tests. It was found that the bioactive compound release was facilitated by PEG. The antifungal activities of the obtained materials against P. chlamydospora and P. aleophilum were studied. We have demonstrated that 5-Cl8Q is an efficient and sustainable antifungal agent against P. chlamydospora and P. aleophilum. Moreover, for the first time, the present study reveals the possibility of using electrospun polymer membranes containing 5-Cl8Q which impede the penetration and growth of P. chlamydospora and P. aleophilum. Thus, the obtained fibrous materials can be suitable candidates for plant protection against diverse fungi.

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Section: Resultssupporting

confidence: 87%

Electrospun 5-chloro-8-hydroxyquinoline-Loaded Cellulose Acetate/Polyethylene Glycol Antifungal Membranes Against Esca

et al. 2019

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“…The FTIR spectra of the CA fibrous materials showed bands characteristic of CA appearing at 1740 cm −1 for the C=O groups, at 1369 and 1226 cm −1 for the CH 3 groups, and at 1037 cm −1 for the ether C–O–C groups [ 25 ]. In the FTIR spectra of CA/5-Cl8Q fibrous mats, in addition to the characteristic bands of CA, a new band appeared at 1500 cm −1 , characteristic for the quinoline ring, proving the presence of the bioactive compound in the electrospun mat [ 26 ]. Clearly, no interaction between CA and 5-Cl8Q was detected on the FT-IR spectra of CA/5-Cl8Q fibrous materials.…”

Section: Resultsmentioning

confidence: 99%

“…pound in the electrospun mat [26]. Clearly, no interaction between CA and 5-Cl detected on the FT-IR spectra of CA/5-Cl8Q fibrous materials.…”

Section: Composition Of Fibrous Materials: Morphology and Propertiesmentioning

confidence: 89%

Cellulose Acetate-Based Electrospun Materials with a Variety of Biological Potentials: Antibacterial, Antifungal and Anticancer

et al. 2021

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Novel eco-friendly fibrous materials with complex activities from cellulose acetate and cellulose acetate/polyethylene glycol (CA,PEG) containing 5-chloro-8-hydroxyquinoline as a model drug were obtained by electrospinning. Several methods, including scanning electron microscopy, X-ray diffraction analysis, ultraviolet-visible spectroscopy, water contact angle measurements, and mechanical tests, were utilized to characterize the obtained materials. The incorporation of PEG into the fibers facilitated the drug release. The amounts of the released drug from CA/5-Cl8Q and CA,PEG/5-Cl8Q were 78 ± 3.38% and 86 ± 3.02%, respectively (for 175 min). The antibacterial and antifungal activities of the obtained materials were studied. The measured zones of inhibition of CA/5-Cl8Q and CA,PEG/5-Cl8Q mats were 4.0 ± 0.18 and 4.5 ± 0.2 cm against S. aureus and around 4.0 ± 0.15 and 4.1 ± 0.22 cm against E. coli, respectively. The complete inhibition of the C. albicans growth was detected. The cytotoxicity of the obtained mats was tested toward HeLa cancer cells, SH-4 melanoma skin cells, and mouse BALB/c 3T3 fibroblasts as well. The CA/5-Cl8Q and CA,PEG/5-Cl8Q materials exhibited anticancer activity and low normal cell toxicity. Thus, the obtained fibrous materials can be suitable candidates for wound dressing applications and for application in local cancer treatment.

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“…A new band appeared at 1500 cm −1 , characteristic for the aromatic ring of the chemical fungicide in the PLLA/5-Cl8Q and PLLA/K5N8Q fibrous materials (Figure 3), in addition to the characteristic bands of PLLA [37], proving its presence in the electrospun composite materials.…”

Section: Ftir Spectroscopic Analysismentioning

confidence: 95%

Electrospun Polymer-Fungicide Nanocomposites for Grapevine Protection

et al. 2021

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Nowadays, diseases in plants are a worldwide problem. Fungi represent the largest number of plant pathogens and are responsible for a range of serious plant diseases. Esca is a grapevine disease caused mainly by fungal pathogens Phaeomoniella chlamydospora (P. chlamydospora) and Phaeoacremonium aleophilum (P. aleophilum). The currently proposed methods to fight esca are not curative. In this study, polymer composites based on biodegradable polymer containing chemical fungicides with antifungal activity were successfully prepared by electrospinning. The obtained materials were hydrophobic with good mechanical properties. In vitro studies demonstrated that the fungicide release was higher from PLLA/K5N8Q fibrous mats (ca. 72% for 50 h) compared to the released drug amount from PLLA/5-Cl8Q materials (ca. 52% for 50 h), which is due to the better water-solubility of the salt. The antifungal activity of the fibrous materials against P. chlamydospora and P. aleophilum was studied as well. The incorporation of the fungicide in the biodegradable fibers resulted in the inhibition of fungal growth. The obtained materials are perspective candidates for the protection of vines from the penetration and growth of fungal pathogens.

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Synthesis, Characterization and Antimicrobial Activity of Metal Chelates of 5‐[1(H)‐Benzotriazole methylene]‐8‐quinolinol

Cited by 10 publications

References 4 publications

Electrospun 5-chloro-8-hydroxyquinoline-Loaded Cellulose Acetate/Polyethylene Glycol Antifungal Membranes Against Esca

Electrospun 5-chloro-8-hydroxyquinoline-Loaded Cellulose Acetate/Polyethylene Glycol Antifungal Membranes Against Esca

Cellulose Acetate-Based Electrospun Materials with a Variety of Biological Potentials: Antibacterial, Antifungal and Anticancer

Electrospun Polymer-Fungicide Nanocomposites for Grapevine Protection

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