Synthesis, characterization, and antimicrobial activity of 3′‐(4‐(2‐substituted thiazol‐4‐yl)phenyl)spiro[indoline‐3,2′‐thiazolidine]‐2,4′‐diones

Abstract

magnified image A series of 3′‐(4‐(2‐methyl/phenyl/benzylthiazol‐4‐yl)phenyl)spiro[indoline‐3,2′‐thiazolidine]‐2,4′‐diones was synthesized. The structures of the synthesized compounds were evaluated by analytical and spectral (IR, 1H NMR, 13C NMR, LC‐MS, and elemental analysis) methods. All the synthesized compounds were screened for qualitative (Zone of inhibition) and quantitative antimicrobial activities (MIC). Most of the derivatives showed good activity towards Gram‐positive and Gram‐negative bacteria. J. Heterocyclic Chem., (2010).

Synthesis, Structural Characterization, and Biological Evaluation of Novel Substituted 1,3‐Thiazole Derivatives Containing Schiff Bases

“…The syntheses of thiazole and its heterocyclic derivatives have been increasingly investigated for years owing to their various biological activities, including antifungal , antibacterial , anti‐inflammatory , anticonvulsant , anti‐cancer , antihypertensive , anti‐HIV , and anti‐tuberculosis properties . Additionally, according to various studies conducted on thiazole and its derivatives, some of the compounds reportedly can be used to make polymers, liquid crystals, fluorescent dyes, herbicides, and insecticides .…”

Synthesis and Antimicrobial Activities of Novel Series of 3‐(4‐(2‐substituted thiazol‐4‐yl)phenyl)‐2‐(4‐methyl‐2‐substituted thiazol‐5‐yl)thiazolidin‐4‐one Derivatives

“…The thiazolidinone nucleus containing compounds show anti‐inflammatory , anticonvulsant , hypnotic and anti‐tubercular , and antimicrobial and anticancer activities. In view of these observations and as a continuation of our previous work on thiazolidinone , it was thought to synthesize new thiazole based 1,3‐thiazolidin‐4‐one by the condensation of 2‐substituted‐4‐methylthiazole‐5‐carbaldehyde with 4‐(2‐substituted thiazol‐4‐yl)benzene‐amine and thioglycolic acid.…”

Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction

“…Spirocyclic oxindoles are valuable synthetic intermediates and constitute the core units of many pharmacological agents and alkaloids [ 1 , 2 , 3 ]. These compounds have attracted much attention from synthetic chemists due to their diverse biological activities including antimycobacterial [ 4 , 5 , 6 , 7 , 8 , 9 ], antitumor [ 10 , 11 , 12 , 13 , 14 ], antimicrobial [ 15 ], antibacterial [ 16 , 17 ], antifungal [ 18 , 19 ], antiviral [ 20 , 21 ], and local anesthetic [ 22 ] properties. Hence, a number of synthetic routes have been developed for the preparation of these structural frameworks [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ].…”