Synthesis, characterization and antimicrobial activity of salicylaldehyde benzenesulfonylhydrazone (Hsalbsmh)and its Nickel(II), Palladium(II), Platinum(II), Copper(II), Cobalt(II) complexes

Aslan, Halime Güzin; Özcan, Servet; Karacan, Nurcan

doi:10.1016/j.inoche.2011.05.024

Cited by 61 publications

(35 citation statements)

References 21 publications

(16 reference statements)

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“…1 H NMR chemical shifts are reported in ppm and are referenced to residual protons in deuterated solvent at 400 MHz. 13 C NMR chemical shifts are referenced to solvent carbon resonances as internal standards at 100 MHz. Multiplicities are reported as singlet (s), doublet (d), triplet (t), quartet (q), quintet (quint), multiplet (m), broad (br), and overlapping (ov) with coupling constants (J) reported in hertz.…”

Section: Experimental Materials and Methodsmentioning

confidence: 99%

“…1 H NMR (CDCl 3 ) d: 13.54 (br s, 1H, OH), 8.24 (s, 1H, C(H) = N), 7.36-7.32 (ov m, 2H, Ar), 6.83 (d, J = 8.7 Hz, 1H, Ar), 3.60 (t, J = 6.9 Hz, 2H, NCH 2 ), 1.68 (m, 1H, CH 2 CH), 1.57 (app q, J = 6.9 Hz, 2H, CH 2 CH), 0.93 (d, J = 6.9 Hz, 6H, CH(CH 3 ) 2 ). 13 …”

Section: Synthesis Of (E)-4-bromo-2-((isopentylimino)methyl)phenol (1a)mentioning

confidence: 99%

“…Indeed, metals are now known to play a critical role in neurological disorders [2], chelation therapy in cases of metal poisoning [3], antimicrobial studies [4], and in the treatment of cancer [5,6]. One area that has received considerable recent attention stems from the observation that simple copper(II) [7] and palladium(II) complexes [8][9][10][11][12][13] display potent antifungal and antibacterial properties. The development of drug-resistant bacteria has reinforced the importance of research focused on using metal-based complexes in medicine, as the mechanism of action of inorganic compounds differs from that of traditional organic-based treatments [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and antimicrobial properties of lipophilic Schiff base copper and palladium complexes

Daley

Moffat

Wilson

et al. 2015

Transition Met Chem

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The reaction of Cu(II) sulfate or Pd(II) acetate with four salicylaldimines derived from 5-bromosalicylaldehyde and long-chain aliphatic primary amines afforded the corresponding metal complexes 2a-d and 3a-d, respectively. All complexes were characterized by physicochemical and spectroscopic methods. The molecular structure of 2b was determined by a single-crystal X-ray diffraction study. All complexes were tested for their potential antifungal and antibacterial activities.

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Section: Experimental Materials and Methodsmentioning

confidence: 99%

Section: Synthesis Of (E)-4-bromo-2-((isopentylimino)methyl)phenol (1a)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and antimicrobial properties of lipophilic Schiff base copper and palladium complexes

Daley

Moffat

Wilson

et al. 2015

Transition Met Chem

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“…However, as a consequence of the rapid hydrolysis in aqueous solutions and lower bioactivity of palladium complexes, an appropriate ligand system which can sustain the biological environment is required [20]. Several palladium complexes with different nitrogen ligands have been designed for biological applications [21][22][23][24][25][26][27][28][29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Carbohydrate triazole tethered 2-pyridyl-benzimidazole ligands: Synthesis of their palladium (II) complexes and antimicrobial activities

Deepthi

Ramesh

Trivedi

et al. 2015

Inorganica Chimica Acta

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“…Among them, hydrazones have attracted special attention from researchers due to their well known chelating capability and structural flexibility that can provide rigidity to the skeletal framework of the prepared metal complexes. [1][2][3][4][5] Hydrazones and analogous compounds play an important role in improving the selectivity and toxicity profile of certain antitumor agents by forming drug carrier systems employing suitable carrier proteins. 6 The real impetus towards developing the coordination chemistry of these hydrazones has been provided by the remarkable biological activities exhibited by them that are related to their metal complexing ability.…”

Section: Introductionmentioning

confidence: 99%

Copper(i) and nickel(ii) complexes with 1 : 1 vs. 1 : 2 coordination of ferrocenyl hydrazone ligands: Do the geometry and composition of complexes affect DNA binding/cleavage, protein binding, antioxidant and cytotoxic activities?

et al. 2012

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A new series of geometrically different complexes containing ferrocenyl hydrazone ligands were synthesised by reacting suitable precursor complex [MCl 2 (PPh 3 ) 2 ] with the ligands HL 1 or HL 2 (where M = Cu(II) or Ni(II); HL(5) and [Ni(L 2 ) 2 ] (6) were characterised by various spectral studies. Among them, complexes 3 and 5 characterised by single crystal X-ray diffraction showed a distorted tetrahedral structure for the former with 1 : 1 metal-ligand stoichiometry, but a distorted square planar geometry with 1 : 2 metal-ligand stoichiometry in the case of the latter. Systematic biological investigations like DNA binding, DNA cleavage, protein binding, free radical scavenging and cytotoxicity activities were carried out using all the synthesised compounds and the results obtained were explained on the basis of structure-activity relationships. The binding constant (K b ) values of the synthesised compounds are found to be in the order of magnitude 10 3 -10 5 M −1 and also they exhibit significant cleavage of supercoiled (SC) pUC19 DNA in the presence of H 2 O 2 as co-oxidant. The conformational changes of bovine serum albumin (BSA) upon binding with the above complexes were also studied. In addition, concentration dependent free radical scavenging potential of all the synthesised compounds (1-6) was also carried out under in vitro conditions. Assays on the cytotoxicity of the above complexes against HeLa and A431 tumor cells and NIH 3T3 normal cells were also carried out. † Electronic supplementary information (ESI) available: Crystal packing diagram of the unit cell of complexes 3 and 5 (Fig. S1 and S2), Electronic absorption spectra of binding of ligands 1 and 2 with DNA (Fig. S3), Electronic absorption spectra of binding of complexes 3, 4 and 5 with DNA (Fig. S4 and S5), Circular dichroism spectra of DNA and ligands 1 and 2 (Fig. S6), Circular dichroism spectra of DNA and complexes 3, 4 (Fig. S7), Emission spectra of binding of complexes 3, 4 and 5 with BSA (Fig. S8 and S9), Synchronous spectra (Δλ = 15 and 60 nm) of binding of complexes 3, 4 and 5 with BSA (Fig. S10, S11 and S12). CCDC reference numbers 796259 and 822888 for complexes 3 and 5.

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Synthesis, characterization and antimicrobial activity of salicylaldehyde benzenesulfonylhydrazone (Hsalbsmh)and its Nickel(II), Palladium(II), Platinum(II), Copper(II), Cobalt(II) complexes

Cited by 61 publications

References 21 publications

Synthesis and antimicrobial properties of lipophilic Schiff base copper and palladium complexes

Synthesis and antimicrobial properties of lipophilic Schiff base copper and palladium complexes

Carbohydrate triazole tethered 2-pyridyl-benzimidazole ligands: Synthesis of their palladium (II) complexes and antimicrobial activities

Copper(i) and nickel(ii) complexes with 1 : 1 vs. 1 : 2 coordination of ferrocenyl hydrazone ligands: Do the geometry and composition of complexes affect DNA binding/cleavage, protein binding, antioxidant and cytotoxic activities?

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