Synthesis, characterization and antimicrobial activity of nickel(II) complexes of tridentate N3 ligands

Das, Athulya; Rajeev, Anjana; Bhunia, Sarmistha; Arunkumar, M.; Nithya, C.; Sankaralingam, Muniyandi

doi:10.1016/j.ica.2021.120515

Cited by 11 publications

(4 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of metformin complexes with group 10 transition metals have been investigated in the context of their antibacterial activity. In particular, various Ni(II) complexes demonstrated significant activity against a panel of bacterial strains [139][140][141]. The reaction of 2 equiv.…”

Section: Group X (Ni Pd Pt)mentioning

confidence: 99%

Biological Properties of Transition Metal Complexes with Metformin and Its Analogues

2022

View full text Add to dashboard Cite

Metformin is a widely prescribed medication for the treatment and management of type 2 diabetes. It belongs to a class of biguanides, which are characterized by a wide range of diverse biological properties, including anticancer, antimicrobial, antimalarial, cardioprotective and other activities. It is known that biguanides serve as excellent N-donor bidentate ligands and readily form complexes with virtually all transition metals. Recent evidence suggests that the mechanism of action of metformin and its analogues is linked to their metal-binding properties. These findings prompted us to summarize the existing data on the synthetic strategies and biological properties of various metal complexes with metformin and its analogues. We demonstrated that coordination of biologically active biguanides to various metal centers often resulted in an improved pharmacological profile, including reduced drug resistance as well as a wider spectrum of activity. In addition, coordination to the redox-active metal centers, such as Au(III), allowed for various activatable strategies, leading to the selective activation of the prodrugs and reduced off-target toxicity.

show abstract

Section: Group X (Ni Pd Pt)mentioning

confidence: 99%

Biological Properties of Transition Metal Complexes with Metformin and Its Analogues

2022

View full text Add to dashboard Cite

show abstract

“…There are reports known where the employed ligands coordinate in a facial manner to the transition metal, especially when a twofold excess of ligand is used. [42][43][44][45] Elemental analysis confirms the formation of MnĲII)ĲOTf) 2 -L 1 as the coordinating MeCN is removed in vacuo when drying the crystals before measurement. Accordingly, HRMS shows [M-OTf] + .…”

Section: Catalyst Characterisationmentioning

confidence: 99%

Manganese N,N,N-pincer complex-catalyzed epoxidation of unactivated aliphatic olefins

Verspeek

Ahrens

Spannenberg

et al. 2022

Catal. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…These Schiff bases which constitute an important class of ligands are ubiquitous in coordination chemistry because of the many coordination possibilities they offer. Several studies have reported bi-, tri-, tetra-, pentaand hexadentate Schiff bases [1][2][3][4][5]. These Schiff bases usually have donor sites of the O, N, S type and form stable chelates with various configurations.…”

Section: Introductionmentioning

confidence: 99%

Syntheses, Characterization, and X-Ray Crystal Structure of a 1:1 Co-Crystal of bis{bis[((2-(1H-imidazol-2-yl)methylidene)amino)phenolato-κ3N,N’,O]nickel(II)} and bis{bis[((2-(1H-imidazol-2-yl)methylidene) amino)phenol-κ3N,N’,O]nickel(II)} tetra(chloride)

Diop

Seck

Thiam

et al. 2022

EJCS

View full text Add to dashboard Cite

The present investigation describes the synthesis and structural study of the ligand 2-((1H-imidazol-2-yl)methyleneamino)phenol, which was used to generate three dimensio-nal supramolecular complex formulated as {[Ni(HL)2]2.[Ni(H2L)2]2.(Cl)4.(H2O)5}. The title compound crystallizes in the orthorhombic space group Fddd with the following unit cell parameters: a = 13.9269(4) Å, b = 29.5295(16) Å, c = 43.1739(15) Å, V = 17755.5(12) Å3, Z = 8, R1 = 0.043 and wR2 = 0.129. For this compound, the structure reveals that one neutral mononuclear unit [Ni(HL)2] and one cationic mononuclear unit [Ni(H2L)2]2+. In the neutral unit, the organic molecule acts as a tridentate through one imino nitrogen atom, one nitrogen atom from the imidazole ring and one phenolate oxygen atom. In the cationic unit, it acts as tridentate through one imino nitrogen atom, one nitrogen atom from the imidazole ring and one oxygen atom of non-deprotonated phenol group. In both units the nickel(II) ion is hexacoordinated and the coordination environment can be described as distorted octahedral geometry. Numerous hydrogen bonds link the molecules into three dimensional network.

show abstract

Synthesis, characterization and antimicrobial activity of nickel(II) complexes of tridentate N3 ligands

Cited by 11 publications

References 50 publications

Biological Properties of Transition Metal Complexes with Metformin and Its Analogues

Biological Properties of Transition Metal Complexes with Metformin and Its Analogues

Manganese N,N,N-pincer complex-catalyzed epoxidation of unactivated aliphatic olefins

Syntheses, Characterization, and X-Ray Crystal Structure of a 1:1 Co-Crystal of bis{bis[((2-(1H-imidazol-2-yl)methylidene)amino)phenolato-κ3N,N’,O]nickel(II)} and bis{bis[((2-(1H-imidazol-2-yl)methylidene) amino)phenol-κ3N,N’,O]nickel(II)} tetra(chloride)

Contact Info

Product

Resources

About