Synthesis, Characterization and Antihypertensive Activity of Some New Substituted Pyridazine Derivatives

Mishra, Ravinesh; Siddiqui, Anees A.; Husain, Asif; Rashid, Mohd; Prakash, Atish; Tailang, Mukul; Kumar, M. Sathish; Srivastava, Neeti

doi:10.4067/s0717-97072011000400006

Cited by 11 publications

(4 citation statements)

References 18 publications

(18 reference statements)

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“…In this work, an antihypertensive agent 2-(2,6-dichlororbenzylidenehydrazino)-1,4,5,6-tetrahydropyrimidine hydrochloride ( 3 ) (OT-24) was synthesized as the anti-isomer ( E -isomer) by the experimentation of the nuclear Overhauser effect (NOE) and, by a process of irradiation with ultraviolet light in an aqueous or methanolic solution, it was instantly converted to its syn-isomer ( Z -isomer). Not long ago, the compound ( Z )-2-(2-(2,6-dichlorobenzylidene)hydrazinyl)pyrimidine ( 4 ) and its related 2-benzylidenehydrazinopyrimidine derivatives exhibited remarkable antibacterial activity as shown below in Figure 3 [ 63 ].…”

Section: Applications Of Heterocyclic Compoundsmentioning

confidence: 99%

Fluorescent and Phosphorescent Nitrogen-Containing Heterocycles and Crown Ethers: Biological and Pharmaceutical Applications

Ullah

Khan

et al. 2022

Molecules

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Fluorescent molecules absorb photons of specific wavelengths and emit a longer wavelength photon within nanoseconds. Recently, fluorescent materials have been widely used in the life and material sciences. Fluorescently labelled heterocyclic compounds are useful in bioanalytical applications, including in vivo imaging, high throughput screening, diagnostics, and light-emitting diodes. These compounds have various therapeutic properties, including antifungal, antitumor, antimalarial, anti-inflammatory, and analgesic activities. Different neutral fluorescent markers containing nitrogen heterocycles (quinolones, azafluoranthenes, pyrazoloquinolines, etc.) have several electrochemical, biological, and nonlinear optic applications. Photodynamic therapy (PDT), which destroys tumors and keeps normal tissues safe, works in the presence of molecular oxygen with light and a photosensitizing drugs (dye) to obtain a therapeutic effect. These compounds can potentially be effective templates for producing devices used in biological research. Blending crown compounds with fluorescent residues to create sensors has been frequently investigated. Florescent heterocyclic compounds (crown ether) increase metal solubility in non-aqueous fluids, broadening the application window. Fluorescent supramolecular polymers have widespread use in fluorescent materials, fluorescence probing, data storage, bio-imaging, drug administration, reproduction, biocatalysis, and cancer treatment. The employment of fluorophores, including organic chromophores and crown ethers, which have high selectivity, sensitivity, and stability constants, opens up new avenues for research. Fluorescent organic compounds are gaining importance in the biological world daily because of their diverse functionality with remarkable structural features and positive properties in the fields of medicine, photochemistry, and spectroscopy.

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Section: Applications Of Heterocyclic Compoundsmentioning

confidence: 99%

Fluorescent and Phosphorescent Nitrogen-Containing Heterocycles and Crown Ethers: Biological and Pharmaceutical Applications

Ullah

Khan

et al. 2022

Molecules

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“…Each rat was placed in restrainer and appropriate cuff with sensor was mounted on its tail and warmed to about 33-35 ° C. The tail cuff was inflated to a pressure above 200 mmHg, systolic blood pressure; diastolic blood pressure and heart rate were measured directly by the tail cuff and pulse sensor. 15…”

Section: Hypotensive Activity In Normotensive Ratsmentioning

confidence: 99%

Anti-Hypertensive Activity of Punica granatum peels Ethyl Acetate Extract on Fludrocortisones Induced Hypertension in Wistar Rats ArticleView

Monir¹,

Elkarim²,

Shalaby³

et al. 2020

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Pomegranate (Punica granatum Linn.) has several medicinal properties. Pomegranate juice has been reported to be an effective source of high amounts of phyto-constituents with many health and nutritional benefits. This work assessed the possible effect on blood pressure (B.P) and heart rate of P. granatum peel ethyl acetate extract (PGE) at a dosage of 400 mg / kg / day on hypertension-induced fludrocortisone Wistar rats. PGE therapy substantially lowered the B.P of hypertensive rats treated with salt fludrocortisones, but the mean blood pressure and heart rate in normotensive rats were not altered. In isolated aortic strip, the contractile reactions to noradrenalin of PGE-treated hypertensive rats have been substantially reduced. The active fraction was purified by successive chromatographic techniques resulted in isolation of quercetin and ursolic acid, this bioactive mixture induced a significant decrease in the blood pressure of hypertensive rats as compared to hypertensive control rats at a concentration of 10 mg/kg.

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“…From this research study, authors concluded that incorporation of amino and carboxylic acid groups into the structure of pyridazinone derivatives can enhance the ACE inhibitory activity of this class of compounds. Moreover, R. Mishra et al, [38] introduced a series of 4,5-dihydro-1H-(1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives and evaluated their antihypertensive activity using Tail Cuff method. This study revealed that compounds 34 and 35 reduced the mean arterial blood pressure (MABP) by (41.84 and 40.98%), respectively in comparable results to the standard drugs propranolol and hydralazine (41.40 and 41.76%), respectively.…”

Section: Antihypertensive Activitymentioning

confidence: 99%

Pyridazinones and pyrrolones as promising Scaffolds in Medicinal Chemistry

Abdelbaset

Abdel‐Aziz

Abuo‐Rahma

et al. 2018

Journal of advanced Biomedical and Pharmaceutical Sciences

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Pyridazinones and pyrrolones are important building blocks for some important drugs such as the naturally occurring antibacterial pyrrolone, althiomycin; the cardiotonic pyridazinones, pimobendan and levosimendan and the analgesic anti-inflammatory, emorfozan. Therefore, researchers all over the world paid attention to prepare various pyridazinones and pyrroolones derivatives. The variability in the biological response and ease of preparation from the corresponding furanones attracted attention of researchers to explore these two nuclei in the design and synthesis of different analogues. This review article focuses on different biological activities, structure activity relationship and mechanism of action of pyridazinones and pyrrolones derivatives.

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Synthesis, Characterization and Antihypertensive Activity of Some New Substituted Pyridazine Derivatives

Cited by 11 publications

References 18 publications

Fluorescent and Phosphorescent Nitrogen-Containing Heterocycles and Crown Ethers: Biological and Pharmaceutical Applications

Fluorescent and Phosphorescent Nitrogen-Containing Heterocycles and Crown Ethers: Biological and Pharmaceutical Applications

Anti-Hypertensive Activity of Punica granatum peels Ethyl Acetate Extract on Fludrocortisones Induced Hypertension in Wistar Rats ArticleView

Pyridazinones and pyrrolones as promising Scaffolds in Medicinal Chemistry

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