Synthesis, characterization and antifungal activity of new dithiocarbamate-based complexes of Ni(II), Pd(II) and Pt(II)

Ferreira, Isabella P.; Lima, Geraldo Μ. de; Paniago, Eucler B.; Takahashi, Jacqueline A.; Pinheiro, Carlos B.

doi:10.1016/j.ica.2014.09.002

Cited by 46 publications

(21 citation statements)

References 45 publications

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“…They have versatile binding abilities and form complexes with most transition metals [21,22,23]. algaecides and NO-trapping agents [24,25,26]. They are used as effective antidotes for cadmium intoxication [19].…”

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confidence: 99%

Removal efficiency of Pb, Cd, Cu and Zn from polluted water using dithiocarbamate ligands

Abu‐El‐Halawa

Zabin

2017

Journal of Taibah University for Science

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Presently, there is increased attention and focus on heavy metals, which are becoming one of the most serious environmental problems due to their adverse health effects. These toxic heavy metals are not easily degraded and require removal from polluted water to protect people and the environment. The purpose of this work was to prepare two types of dithiocarbamate ligands, one aliphatic (diethyldithiocarbamate) and the other aromatic (diphenyldithiocarbamate), and to use them as chelators to remove Pb, Cd, Cu and Zn from polluted water. Dithiocarbamates were selected because they have good binding ability and can precipitate metal ions as complexes.The metal removal efficiency is compared between both ligands and also compared to the efficiency of activated carbon in an adsorption process to remove the same metals.The investigation results indicated that the diphenyldithiocarbamate ligand was more efficient in removing the studied metals than the diethyldithiocarbamate analogues.Additionally, the metal removal efficiency of the diphenyldithiocarbamate ligand was more effective than using the activated carbon method.

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confidence: 99%

Removal efficiency of Pb, Cd, Cu and Zn from polluted water using dithiocarbamate ligands

Abu‐El‐Halawa

Zabin

2017

Journal of Taibah University for Science

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“…Results from various studies on metal complexes, especially dithiocarbamates and the necessary knowledge of their biocide action still justify newly synthesized metal–containing dithiocarbamate complex physical, chemical [10] and antibacterial properties. Given this, a new series of transition metal Ni (II), Cu(II) complexes of morpholine dithiocarbamate (MDTC) ligands were prepared and characterized by element analysis, conductivity, and magnetic measurements.…”

Section: Introductionmentioning

confidence: 99%

Syntheses, physicochemical characterization, antibacterial studies on potassium morpholine dithiocarbamate nickel (II), copper (II) metal complexes and their ligands

Balakrishnan

Duraisamy

Murugan

et al. 2019

Heliyon

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Organic molecule dithiocarbamate transition metal complexes are novel and very attractive pharmaceutical targets for the management and control of antibiotic resistant bacteria. The direct reaction has synthesized new transition metal nickel (II), copper (II) complexes of potassium morpholine dithiocarbamate (K + C 5 H 8 NOS 2 − ) ligands and characterized by UV-visible spectroscopy, Fourier-transform infrared spectroscopy (FTIR), as well as NMR physicochemical techniques. Antibacterial bioefficacy of the ligand and its metal complexes has been investigated in vitro on the growth of Gram-positive ( Staphylococcus aureus MTCC 737, Bacillus cereus MTCC 1272) and the Gram-negative ( Listeria monocytogenes MTCC 657, Shigella flexeneri MTCC 1457) bacteria. The obtained electronic spectral bands are characteristic and consistent with the proposed composition of the ligand as well as its metal complexes. It also provides a further example of the bidentate coordination of dithiocarbamate ligands. Absorption peak values of FTIR are characteristic of the ligand as well as dithiocarbamate group molecules and exhibit their metal coordination. NMR 1 H signal variations also correlate with the coordination mediated chemical shifts. Both the metal complexes showed significant antibacterial activity. However, enhanced antimicrobial activity of the ligands than metal complexes against Gram positive and Gram negative bacteria were observed. Thus, further study on this approach could pave a way for the development of dithiocarbamate-metal complex based antibacterial agent.

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“…In this context, metal based drugs are the optimum choice as they might be more bio‐specific yet less hazardous to the host. Metal based antibacterial and antifungal agents are benign to environment as well . Palladium(II), a d 8 system, forms a significant number of coordination compounds having structural and thermodynamic resemblance with its congener, platinum(II) .…”

Section: Introductionmentioning

confidence: 99%

“…Polyenes and azoles are two main classes of antifungal organic drugs. Apart from those, sulphur based ligands like dithiocarbamates and their Ni(II), Pd(II) or Pt(II) complexes can also act as fungicides . Again, palladium(II) complexes prepared from nitrogen and sulphur containing ligands like heterocyclic thiolates, thiodiamines or thiosemicarbazides exhibit promising antifungal and/or antibacterial activities.…”

Section: Introductionmentioning

confidence: 99%

Promising Antimicrobial Activity of an Oxime Based Palladium(II) Complex

et al. 2017

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This work delineates with the development of a novel oxime based palladium complex as a promising antimicrobial agent. A novel oxime based ligand, 3-[(2-hydroxy-naphthalen-1-ylmethylene)-hydrazono]-butan-2-one oxime (LH), has been employed to synthesize an orange, monomeric, diamagnetic palladium(II) compound, [Pd(L)(Cl)] (1) in moderate yield. LH is a monocondensate Schiff-base of 2,3-butanedionemonoxime monohydrazone and 2-hydroxy-1-naphthaldehyde in tetrahydrofuran. Both the ligand and its palladium compound have been characterized by spectroscopic and analytical techniques. The X-ray crystal structure of 1 reveals that the palladium center in [Pd(L)(Cl)] is nested in a distorted square-planar 'N 2 OCl' coordination environment. The electrochemical behavior of [Pd (L)(Cl)] in DMF shows a Pd(II)/ Pd(I) irreversible reduction couple. The in vitro antibacterial activity of [Pd(L)(Cl)] was tested against a good number of human pathogenic Grampositive and Gram-negative bacterial cell lines. The in vitro antifungal activity of the titled palladium compound was screened against several pathogenic fungal strains. The promising antimicrobial efficacy of the palladium compound was corroborated through SEM study.

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Synthesis, characterization and antifungal activity of new dithiocarbamate-based complexes of Ni(II), Pd(II) and Pt(II)

Cited by 46 publications

References 45 publications

Removal efficiency of Pb, Cd, Cu and Zn from polluted water using dithiocarbamate ligands

Removal efficiency of Pb, Cd, Cu and Zn from polluted water using dithiocarbamate ligands

Syntheses, physicochemical characterization, antibacterial studies on potassium morpholine dithiocarbamate nickel (II), copper (II) metal complexes and their ligands

Promising Antimicrobial Activity of an Oxime Based Palladium(II) Complex

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