Synthesis, Characterization, and Antifouling Potential of Functionalized Copper Nanoparticles

Anyaogu, Kelechi C.; Fedorov, and Andrei V.; Neckers, Douglas C.

doi:10.1021/la800102f

Cited by 187 publications

(102 citation statements)

References 43 publications

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“…The antibacterial properties of copper, silver, and zinc have been widely utilized in advanced coating technologies, such as the design of materials for biomedical devices, hospital equipment, food processing and storage equipment, household materials, and antifouling paints (Mann et al 2002). Biological experiments show that Cu NPs/polymer composites exhibit antimicrobial activity similar to that of conventional copper-based biocides (Anyaogu et al 2008). However, as solubilisation did not fully explain the toxicity of CuO NPs to cell cultures (Karlsson et al 2008) and yeast S. cerevisiae ), other mechanisms of toxicity such as the formation of reactive oxygen species and DNA damage (Karlsson et al 2008) by NPs of CuO has to be considered.…”

Section: Introductionmentioning

confidence: 96%

Copper nanoparticles synthesized by polyol process used to control hematophagous parasites

Ramyadevi¹,

Jeyasubramanian²,

Marikani³

et al. 2011

Parasitol Res

107

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The present study was based on assessments of the anti-parasitic activities of the hematophagous (blood feeding) larvae of malaria vector, Anopheles subpictus Grassi, filariasis vector, Culex quinquefasciatus, Say (Diptera: Culicidae), and the larvae of cattle tick Rhipicephalus (Boophilus) microplus, Canestrini (Acari: Ixodidae). The metallic copper nanoparticles (Cu NPs) synthesized by polyol process from copper acetate as precursor and Tween 80 were used as both the medium and the stabilizing reagent. The efficacy of synthesized Cu NPs was tested against the larvae of blood-sucking parasites. UV-vis spectra characterization was performed, and peak was observed at 575 nm, which is the characteristic to the surface plasmon bond of Cu NPs. The strong surface plasmon absorption band observed at 575 nm may be due to the formation of non-oxidized Cu NPs. X-ray diffraction (XRD) spectral data showed concentric rings corresponding to the 26.79 (111), 34.52 (200), and 70.40 (220) reflections. XRD spectrum of the copper nanoparticles exhibited 2θ values corresponding to the copper nanocrystal. No peaks of impurities are observed in XRD data. The scanning electron micrograph (SEM) showed structures of irregular polygonal, cylindrical shape, and the size range was found to be 35-80 nm. The size of the Cu NPs was measured by atomic force microscope (AFM) in non-contact mode. For imaging by AFM, the sample was suspended in acetone and spins coated on a silicon wafer. The line profile image was drawn by the XEI software and the horizontal line at 6 μm on a 2D AFM image. Research has demonstrated that metallic nanoparticles produce toxicity in aquatic organisms that is due largely to effects of particulates as opposed to release of dissolved ions. Copper acetate solution tested against the parasite larvae exposed to varying concentrations and the larval mortality was observed for 24 h. The larval percent mortality observed in synthesized Cu NPs were 36, 49, 75, 93,100; 32, 53, 63, 73, and 100 and 36, 47, 69, 88, 100 at 0.5, 1.0, 2.0, 4.0, and 8.0 mg/L against A. subpictus, C. quinquefasciatus and R. microplus, respectively. The larval percent mortality shown in copper acetate solution were 16, 45, 57, 66 and 100, 37, 58, 83, 87, and 100 and 41, 59, 79, 100, and 100 at 10, 20, 30, 40, and 50 mg/L against A. subpictus, C. quinquefasciatus, and R. microplus, respectively. The maximum efficacy was observed in Cu NPs and copper acetate solution against the larvae of A. subpictus, C. quinquefasciatus, and R. microplus with LC(50) and r (2) values of 0.95 and 23.47, 1.01 and 15.24, and 1.06 and 14.14 mg/L with r (2) = 0.766; 0.957 and 0.908; 0.946; and 0.816 and 0.945, respectively. The control (distilled water) showed nil mortality in the concurrent assay. The chi-square value was significant at p ≤ 0.05 level. This is the first report on anti-parasitic activity of the synthesized Cu NPs and copper acetate solution.

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Section: Introductionmentioning

confidence: 96%

Copper nanoparticles synthesized by polyol process used to control hematophagous parasites

Ramyadevi¹,

Jeyasubramanian²,

Marikani³

et al. 2011

Parasitol Res

107

View full text Add to dashboard Cite

show abstract

“…Zero-valent copper, copper oxide, ionic copper and copper-containing molecular complexes have all shown some degree of antibacterial property. Recent work suggests that nanoscale forms of copper [4][5][6][7][8] (and other antimicrobial metals; silver [ 9 ] and zinc, [ 10 ] for example) are particularly effective at inhibiting bacterial growth. Though the general mechanism of action for nanoscale metal-based antimicrobial agents is largely unknown, enhanced metal-ion release, [ 11 , 12 ] specifi c action at the organism-nanomaterial interface (e.g., reactive oxide species [ 11 , 13 ] and cell membrane damage [ 12 , 14 , 15 ] ), and combinations thereof have been proposed.…”

Section: Introductionmentioning

confidence: 99%

Copper‐Based Nanostructured Coatings on Natural Cellulose: Nanocomposites Exhibiting Rapid and Efficient Inhibition of a Multi‐Drug Resistant Wound Pathogen, A. baumannii, and Mammalian Cell Biocompatibility In Vitro

Cady¹,

Behnke²,

Strickland³

2011

Adv Funct Materials

191

115

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This paper describes a layer‐by‐layer (LBL) electrostatic self‐assembly process for fabricating highly efficient antimicrobial nanocoatings on a natural cellulose substrate. The composite materials comprise a chemically modified cotton substrate and a layer of sub‐5 nm copper‐based nanoparticles. The LBL process involves a chemical preconditioning step to impart high negative surface charge on the cotton substrate for chelation controlled binding of cupric ions (Cu2+), followed by chemical reduction to yield nanostructured coatings on cotton fibers. These model wound dressings exhibit rapid and efficient killing of a multidrug resistant bacterial wound pathogen, A. baumannii, where an 8‐log reduction in bacterial growth can be achieved in as little as 10 min of contact. Comparative silver‐based nanocoated wound dressings–a more conventional antimicrobial composite material–exhibit much lower antimicrobial efficiencies; a 5‐log reduction in A. baumannii growth is possible after 24 h exposure times to silver nanoparticle‐coated cotton substrates. The copper nanoparticle–cotton composites described herein also resist leaching of copper species in the presence of buffer, and exhibit an order of magnitude higher killing efficiency using 20 times less total metal when compared to tests using soluble Cu2+. Together these data suggest that copper‐based nanoparticle‐coated cotton materials have facile antimicrobial properties in the presence of A. baumannii through a process that may be associated with contact killing, and not simply due to enhanced release of metal ion. The biocompatibility of these copper‐cotton composites toward embryonic fibroblast stem cells in vitro suggests their potential as a new paradigm in metal‐based wound care and combating pathogenic bacterial infections.

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“…In addition, the combination of Cu 2 O and CuPT exhibited high efficiency against the settlement of algae and the growth of other macrofoulers on the coatings. 26 Furthermore, the removal of macroorganisms and slime was observed aer disturbance by natural seawater in situ on the ra. This result suggested that the erosion of the coatings played two complementary roles on exposure to seawater.…”

mentioning

confidence: 60%

Synthesis of zinc-based acrylate copolymers and their marine antifouling application

Chen

Tang

et al. 2017

RSC Adv.

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Marine fouling organisms have caused inconvenience to humans for a long time owing to their high vitality and great destructiveness. Self-polishing antifouling coatings are considered to be among the most effective antifouling technologies. In this study, zinc-based acrylate copolymers (ZnPs) were designed and synthesized using a bifunctional zinc acrylate monomer (ZnM) as a new self-polishing monomer, and three acrylate monomers (namely, methyl methacrylate, ethyl acrylate and 2-methoxyethyl acrylate)were used as comonomers. ZnPs that contained the new ZnM were characterized by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy and gel permeation chromatography. Different antifouling coatings were prepared using the previously mentioned ZnPs as the matrix material, and their erosion properties were investigated using a lab rotor test. A field test of the prepared coatings at various geographical locations showed their excellent antifouling performance as they inhibited the settlement of barnacles in both the South China Sea for 9 months and in the Yellow Sea for at least 15 months. The results of this study highlight that the biocidal ZnP-based coatings are highly promising candidates for marine antifouling applications.

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Synthesis, Characterization, and Antifouling Potential of Functionalized Copper Nanoparticles

Cited by 187 publications

References 43 publications

Copper nanoparticles synthesized by polyol process used to control hematophagous parasites

Copper nanoparticles synthesized by polyol process used to control hematophagous parasites

Copper‐Based Nanostructured Coatings on Natural Cellulose: Nanocomposites Exhibiting Rapid and Efficient Inhibition of a Multi‐Drug Resistant Wound Pathogen, A. baumannii, and Mammalian Cell Biocompatibility In Vitro

Synthesis of zinc-based acrylate copolymers and their marine antifouling application

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