Synthesis, characterization, and anticancer properties of iminophosphineplatinum(II) complexes containing boronate esters

Abstract

Three new iminophosphines containing pinacol-derived boronate esters have been prepared and ligated to dichloridoplatinum(II) fragments. All compounds have been characterized fully, including an X-ray diffraction study carried out for the platinum complex 8, which is derived from 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline. These three new platinum complexes, along with the non-boron containing control, have been examined for their initial cytotoxic properties against two glioma cell lines using the MTT method.

Boron-containing capsaicinoids

“…The desboro-aryl amine substrates were subjected to EDCIassisted amidation using terminally unsaturated aliphatic acids to provide intermediates (27)(28)(29)(30) towards the nal tertiary amide capsaicinoids (31)(32)(33)(34). These intermediates were subjected to metal-catalyzed hydroboration, employing [IrCl(cod)(dppm)] 45 and pinacolborane (HBpin, pin ¼ 1,2-O 2 C 2 Me 4 ) at room temperature.…”

Diiodido-bis{N-[2-(diphenylphosphino)benzylidene]benzylamine-κ2N,P}dicopper(I)

“…Imine formation is a very efficient process, which does not require demanding reaction procedures. In principle, all types of primary amines-aromatic or aliphatic-react in high yields under mild conditions [9][10][11][12][13][14][15][16][17][18][19][20][21]. In this context, of particular interest might be the use of oligo-amines, which lead to the formation of polydentate P∩N ligands [22,23], or the use of chiral amines [24].…”