Synthesis, characterization and anticancer properties: A series of highly selective palladium(II) substituted-terpyridine complexes

Conjugation of an anti-metabolite nucleobase analogue with a mitochondriotropic agent via palladium(II) against breast cancer cells

“…Compounds containing Pd(II) with diverse ligands featuring various donor atoms have demonstrated a range of activities including antitumor, anti-inflammatory, antibacterial, antiviral, and antifungal effects (Garoufis et al, 2009;Kapdi and Fairlamb, 2014;Banti et al, 2015;Fanelli et al, 2016;Lazarevic et al, 2017;Carneiro et al, 2020). In particular, numerous palladium or platinum complexes showcase cytotoxicity against tumor cells resistant to cisplatin, sometimes exhibiting superior activity compared to cisplatin itself (Garoufis et al, 2009;Hernández et al, 2016;Pruchnik et al, 2016;Espino et al, 2020;Schlagintweit et al, 2021;Bera et al, 2022;Priyanka Dorairaj et al, 2022;Chen et al, 2023;Haribabu et al, 2023;Wang et al, 2023).…”

Fabrication of thiosemicarbazone-based Pd(ii) complexes: structural elucidations, catalytic activity towards Suzuki–Miyaura coupling reaction and antitumor activity against TNBC cells

“…In several cases, palladium( ii ) complexes have shown better antitumor activity than their platinum analogues (cis-platin and carboplatin). 22,26,27…”