Synthesis, characterization and antibacterial studies of Tm(III), Yb(III) and Lu(III) complexes of morin

Woźnicka, Elżbieta; Zapała, Lidia; Pieniążek, Elżbieta; Kosińska, Małgorzata; Ciszkowicz, Ewa; Lecka-Szlachta, Katarzyna; Pusz, J.; Maciołek, Urszula; Dronka, Janusz

doi:10.1080/00958972.2017.1291935

Cited by 13 publications

(2 citation statements)

References 22 publications

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“…The antibacterial activities against Gram-negative Escherichia coli (ATCC 10536), Pseudomonas aeruginosa (ATCC 6538), and Gram-positive Staphylococcus aureus (ATCC 15442) bacteria were determined were determined based on a previously reported protocol and expressed as the minimal inhibitory concentration (MIC) [39][40][41]. The commercially available antibiotics ampicillin, tetracycline, kanamycin, and erythromycin were used as the reference standards (Table 6).…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…The antibacterial activities of thiadiazole ligands and their Zn(II) complexes were determined as minimal inhibitory concentration (MIC) using broth dilution method. All experiments were performed based on the standard protocol [39,40]. The experiments were carried out in 96-well plate and the thiadiazole derivatives were tested within the concentration range of 7.9 µg/mL to 1 mg/mL.…”

Section: Antibacterial Activity Assaymentioning

confidence: 99%

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Structural Features of 1,3,4-Thiadiazole-Derived Ligands and Their Zn(II) and Cu(II) Complexes Which Demonstrate Synergistic Antibacterial Effects with Kanamycin

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Matwijczuk

Kamiński

et al. 2020

IJMS

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Classical synthetic protocols were applied for the isolation of three novel 1,3,4-thiadiazole derivatives which were then complexed with the biologically important Cu(II) and Zn(II) ions. All free ligands and their corresponding complexes were characterized using a number of spectroscopic techniques including Ultraviolet-visible (UV–vis), Fluorescence, Infrared (FT-IR), tandem liquid chromatography-mass (LC-MS), X-ray diffraction (XRD), and Nuclear Magnetic Resonance (NMR) spectroscopy (1H, 13C, HSQC, HMBC). The results obtained are consistent with the formation of dihydrate complexes, in which the chelation of the metal ion occurs via one of the thiadiazole nitrogen atoms and the deprotonated hydroxyl group of the neighboring resorcynyl moiety. The Zn(II) complexes utilize a 1:1 ligand–metal ratio, while in the Cu(II) complexes the ligand–metal ratio is 2:1. Although the antibacterial testing identified moderate activity of the compounds against the tested bacterial strains and additionally modest antioxidant activity, a strong synergistic antibacterial effect against Staphylococcus aureus, using concomitant treatment of thiadiazole derivatives with the commercial antibiotic kanamycin, was observed. The most active thiadiazole derivative demonstrated a minimal inhibitory concentration (MIC) of 500 μg/mL while it was 125 μg/mL in the presence of kanamycin. Moreover, in the presence of few thiadiazole derivatives the MIC value of kanamycin decreased from 0.39 μg/mL to 0.5 μg/mL. The antioxidant activity (IC50) of the most active thiadiazole derivative was determined as 0.13 mM which was nearly three-fold lower compared to that of TROLOX (0.5 mM).

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Section: Antibacterial Activitymentioning

confidence: 99%

Section: Antibacterial Activity Assaymentioning

confidence: 99%

Structural Features of 1,3,4-Thiadiazole-Derived Ligands and Their Zn(II) and Cu(II) Complexes Which Demonstrate Synergistic Antibacterial Effects with Kanamycin

Karcz

Matwijczuk

Kamiński

et al. 2020

IJMS

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Aqueous Complexation of Morin and Its Sulfonate Derivative with Lanthanum(III) and Trivalent Lanthanides

et al. 2019

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The complexation of flavonoids Morin and morin-5'-sulfonic acid (MSA) with rare earth metals is studied in aqueous solution using absorption spectroscopy. In this research 50 conditional and 26 "true" equilibrium stability constants of monocomplex species were determined for various values of pH at constant ionic strength I=1 (NaClO4). The interactions are investigated for La3+ and 12 lanthanides (Ce3+,

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A spectrophotometric and DFT study of the behavior of 6-bromoquercetin in aqueous solution

et al. 2019

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Acid-base activity, keto-enol tautomerism and complexing properties of 6beomoquercetin are investigated in water media at different conditions. The constants of dissociation (pKa) have been determined in pH region at various ionic strength. The analysis of protonation process is conducted in strongly acidic solutions of HCl. The complexation were studied with trivalent lanthanides. The stability constant of monocomplex species ML (M(III) =Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Er, Tm, Yb, Lu) have been obtained. For interpretation and verification of received data the DFT calculations were implemented. Abstract 22 23Acid-base activity, keto-enol tautomerism and complexing properties of 6-24 beomoquercetin are investigated in water media at different conditions. The constants of 25 dissociation (pKa) have been determined in pH region at various ionic strength. The analysis 26 of protonation process is conducted in strongly acidic solutions of HCl. The complexation were 27 studied with trivalent lanthanides. The stability constant of monocomplex species ML (M(III) 28 =Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Er, Tm, Yb, Lu) have been obtained. For interpretation and 29 verification of received data the DFT calculations were implemented.30 31 32 33 34 Introduction 35 36 Being secondary metabolites, flavonoids exist ubiquitous in the plant world (Panche et 37 al. 2016). Quercetin or 5,7,3′,4′-flavon-3-ol is the most known and studied ligand from this 38 group of chemicals. The various qualities, such as anticancer (Le Marchand 2002), antibacterial 39 (Cushnie and Lamb, 2005) and antidiabetic (Vinayagam and Xu 2015) activities demonstrate a 40 multifaceted nature of quercetin. The numerous derivatives of quercetin are also show notable 41 biochemical characteristics (Kessler et al 2003; Sotnikova et al 2013; Manach et al 1998). The 42 complexes of flavonoids with all of groups of metals (Kasprzak et al. 2015; Samsonowicz and 43 Regulska 2017) are described in literature primarily for solid-state conditions. 44 The flavonoids exhibit medical and biological properties in water. Nevertheless, 45 the low solubility make them problematic objects for study of standard physical-chemical 46 methods. The solubility of quercetin in H2O at room temperature is about 10 -4 M (Srinivas et 47 al. 2010). In the same time, the necessary concentration for NMR-analysis or potentiometric 48 study is 10 -2 -10 -1 M. In all works where the issue of flavonoids in solution has been discussed 49 the water-ethanol mixtures or non-aqueous liquids were used as solvent. However, under such 50 conditions the behaviour of flavonoids is fundamentally different from biological media. The 51 spectrophotometric technique is one of the few methods that allow to research small amount of 52 sparingly soluble compounds and determine all equilibrium parameters in pure water with 53 concentration <10 -4 M. 54 ∆G aq. ). E zpe is calculated harmonic vibrational frequencies to estimate the zero point energy 104 correction. 105 106 Experimental 107 108 The UV-Vis spectra were m...

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Synthesis, characterization and antibacterial studies of Tm(III), Yb(III) and Lu(III) complexes of morin

Cited by 13 publications

References 22 publications

Structural Features of 1,3,4-Thiadiazole-Derived Ligands and Their Zn(II) and Cu(II) Complexes Which Demonstrate Synergistic Antibacterial Effects with Kanamycin

Structural Features of 1,3,4-Thiadiazole-Derived Ligands and Their Zn(II) and Cu(II) Complexes Which Demonstrate Synergistic Antibacterial Effects with Kanamycin

Aqueous Complexation of Morin and Its Sulfonate Derivative with Lanthanum(III) and Trivalent Lanthanides

A spectrophotometric and DFT study of the behavior of 6-bromoquercetin in aqueous solution

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