Synthesis, Characterization and Antibacterial Studies of (3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid-Cr (III) Complex

Abstract

Benzylpenicillin, also known as (3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic, is a common bactericidal antibiotic of the betalactamin family which is mostly used to treat infections caused by gram-positive bacterial strains and few gram-negative bacterial strains. Cr (III) complex of benzylpenicillin was synthesized by the reaction of benzylpenicillin with CrCl3.6H2O. The structure of the complex was confirmed through elemental analysis, electrical conductivity, FT-IR, electronic spectra, 1H-NMR, and 13C-NMR spectroscopic methods. The physical properties such as solubility, color and melting point were also determined for both the ligand and the complex. The complex has a deep green color. Both the ligand and the complex are ionic (236.0 and 126.0 Sm2.mol-1). From the spectroscopic result, the ligand behaved as a pentadentate ligand coordinating to the metal ion through OH, NH, C=O of amide, carboxylate& β-lactam. A trigonal bipyramidal geometry has been proposed for the metal complex. The prepared complex was evaluated in vitro for its antibacterial activity against some pathogenic gram-positive (Staphylococcus aureus, Bacillus substilis, Bacillus cereus, and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli, Enterobacter cloacae, Pneumonia aeruginosa and Campylobacter fetus). The metal complex showed enhanced antibacterial activity as compared to the uncomplexed ligand.

Sonochemical synthesis and characterization of Fe(II) and Cu(II) nano-sized complexes of sulfamethoxazole

“…These transitions are known as inter-ligand charge transfer (ILCT) [29]. The absorption band at λ = 548 nm observed for the [Fe(SMX)(H 2 O) 2 ] metal complex has been assigned d-d transitions since it was a weak transition [30].…”

Synthesis and characterization of Cr (III)-ascorbic acid complex

“…Among the natural sciences, medicinal inorganic chemistry is still considered a young discipline by many, but this is contrary to the historically proven use of metals in pharmaceutical potions, which traces back to the ancient civilization of Mesoptamia, Egypt, India and China (Orvig and Abram, 1999;Thompson and Orvig, 2006). However, a wide range of biological activities such as antibacterial, antifungal, antitumor, antiviral and antioxidant activities are exhibited by organic compounds and their metal complexes (Otuokere et al, 2021;Otuokere and Robert, 2020;Otuokere et al, 2020;Otuokere and Amadi, 2017;Otuokere et al, 2017;Sokwaibe and Otuokere, 2016;Onyenze et al, 2016). Chromium is widely used in many industries.…”