Synthesis, Characterization and Antibacterial Evaluation of some Novel Benzimidazole Derivatives Containing 1,3,4-Thiadiazole Moiety.

Abstract

A series of novel 5-amino-1,3,4-thiadiazole-2-thiol and 1,3,4-thiadiazole-2,5-dithiol derivatives of benzimidazole were synthesized through nucleophilic substitution reaction of 5-substituted-2-(chloromethyl)-1H-benzimidazole, structures of the synthesized compounds were proved by spectral methods of analysis ( FT-IR, 1 H and 13 C NMR ). All the target compounds were screened for their antibacterial activity toward gram-negative (E.coli, P. aeruginosa) and Gram-positive (B. subtilis, S. aureus) bacteria, most of the synthesized derivatives exhibited good to moderate activity toward both Gram-positive (B. subtilis, S. aureus) and Gram-negative (E.coli, P. aeruginosa) bacteria.

New Functionalized Chitosan with Thio-Thiadiazole Derivative with Enhanced Inhibition of Pathogenic Bacteria, Plant Threatening Fungi, and Improvement of Seed Germination

“…FT-IR (KBr, υ max /cm −1 ) of compound 2 (Figure 1a) exhibited absorption peaks, in accordance with [24,29], at 3275 cm −1 and 3108 cm −1 belonging to the stretching vibrations of the NH 2 group, while the peak at 2948 cm −1 was the symmetric stretching vibration of aliphatic C-H in CH 3 . Also, the absorption peaks at 1629 cm −1 and 1521 cm −1 were correlated with the stretching vibrations of C=N and C=C groups, respectively.…”

A Review on Synthesis, Therapeutic, and Computational Studies of Substituted 1, 3, 4 Thiadiazole Derivatives

“…All the target compounds were screened for their antibacterial activity toward gram-negative (E. coli, P. aeruginosa) and Gram-positive (B. subtilis, S. aureus) bacteria; most of the synthesized derivatives exhibited good to moderate activity toward both Gram-positive (B. subtilis, S. aureus) and Gramnegative (E. coli, P. aeruginosa) bacteria. 46 2-Anticonvulsant activity Novel 1,2,4-triazolo-1,3,4-thiadiazoles 55a-l (Scheme 29) were successfully prepared and estimated for anticonvulsant activity by maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) tests. Entire compounds displayed moderate to good activity.…”

Synthesis and PTP1B/TCPTP Inhibitory Activity Evaluation of Novel 2,5-Disubstituted-1,3,4-thiadiazolamide Derivatives Containing Carbazole/Benzimidazole Moity

“…咔唑和苯并咪唑已成为未来药物设计有吸引力 的模板. 有研究显示, 含咔唑/苯并咪唑环的 1,3,4-噻二 唑衍生物具有抗糖尿病 [21] 、抗癌 [22～24] 、抗菌 [25,26] 、抗抑 郁 [27,28] 、抗氧化 [29] 活性, 但文献调查显示, 含咔唑/苯并 咪唑环的 2,5-二取代-1,3,4-噻二唑酰胺衍生物的合成及 其对 PTP1B 抑制活性的研究尚未见文献报道.…”