Synthesis, characterization, and antibacterial activity of some transition metals with the Schiff base N-(2-furanylmethylene)-3-aminodibenzofuran

Reiss, Aurora; Florea, S.; Căproiu, Theodor; Stănică, Nicolae

doi:10.3906/kim-0807-31

Cited by 9 publications

(4 citation statements)

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“…The electronic spectrum of copper complex 7 exhibited bands at 690 and 550 nm, which may be assigned to 2 B 1g → 2 E g and 2 B 1g → 2 A 1g , respectively 29 . These bands favored distorted octahedral geometry around the Cu(II) ion and were supported by the magnetic moment value of 2.16 BM 30 . Moreover, the meff value of nickel complex 8 is 4.06 B.M.…”

Section: Resultsmentioning

confidence: 70%

Green synthesis of nanosized N,N'-bis(1-naphthylidene)-4,4'-diaminodiphenylmethane and its metal (II) complexes and evaluation of their biological activity

Hassan

Hussien

Elhusseiny

2022

Sci Rep

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Condensation of ecofriendly synthesized 4,4’-methanedianiline with 2-hydroxy-1-naphthaldehyde produced a (1:1) octopus-like Schiff base mixed ligand. Reaction with Co(OAc)2⋅H2O, NiCl2⋅6H2O, Cu(OAc)2⋅H2O and Zn(OAc)2⋅2H2O metals furnished their complexes in high yield and purity. All new structures were fully characterized by various spectroscopic and spectrometric measurements. The complexes exhibited high thermal stability up to 700 °C, leaving nearly 40% of their mass as residues. Antimicrobial screening results exhibited moderate activities towards all studied microbes. Antioxidant screening was concentration dependent, and their activities were in the order Ni(II) > Zn(II) > Cu(II) > Co(II) complexes. The NO inhibitory effect revealed that the nickel complex exhibited the highest activity, whereas the cobalt complex showed the lowest inhibition. All compounds showed a significant lipid peroxidation inhibitory effect against oxidative stress. The complexes significantly diminished the TBARS level, and the nickel complex exhibited the highest inhibition at p < 0.01. Antioxidants stress the oxidative damage induced by iron, indicating that the nickel complex has the highest reducing activity. The inhibitory effect against acetylcholine esterase showed that the copper complex has the highest activity. Membrane stabilization activities clearly indicated that most compounds can improve the integrity of the cells and stability of their membrane, and this result may be related to their antioxidant capacity to protect against cytotoxicity. The nickel complex exhibited a stronger total antioxidant capacity than the other complexes. The biological and antioxidant capacities of these complexes may make them promising candidates in pharmaceutical applications.

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Section: Resultsmentioning

confidence: 70%

Green synthesis of nanosized N,N'-bis(1-naphthylidene)-4,4'-diaminodiphenylmethane and its metal (II) complexes and evaluation of their biological activity

Hassan

Hussien

Elhusseiny

2022

Sci Rep

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“…[26] All complexes possess biological activity [20 ] and which have the same activities. All tested of [M (Curc)(L-dopa)2] mixed-ligand complexes were detected the same activities and good antimicrobial activity, displayed higher activities candida albicans fungus compared to bacteria.as show in Table 4 Figure 5 and Chart 1 [24][25][26],.Antifungal studies towards all tested fungi enhanced activity when coordinated with all metals, on chelation the polarity of the ion due to the overlap of the ligand orbital and partial sharing of the positive charge of the ion with donor groups reduced to a greater extent [27,28] .…”

Section: Biological Activitiesmentioning

confidence: 72%

Preparation, Structural Characterization and Biological Activities of Curcumin-Metal(II)-L-3,4-dihydroxyphenylalanin (L-dopa) complexes

Salh¹,

Al‐Noor²

2023

IHJPAS

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In the present work, a first-row divalent d-transition metal obtained from curcumin(Curc) and L-3,4-dihydroxyphenylalanin(L-dopa)have been synthesized which their complexes and characterized by C.H.N, conductance, spectral methods: FT-IR, Ultra–Visible. Magneto-chemical measurements, molar conductance ΛM (1×10−3 mol/L in DMSO):36- 0.84 ohm-1.cm2.mol-1 (non-electrolyte). The data shows that the complexes have the structure [M((II))-(Curc)-(L-dopa)] system. Electronic and magnetic data suggest an octahedral geometry for all complexes in which the (L-dopa) and curcumin act as bidentate ligands. Curcumin coordinated to the metal ions M (II) through the lone pair of electrons of oxygen in 2(C=O) groups. The (L-dopa) coordinated to M (II) as a mono negative bidentate ligand through the oxygen atom of the carboxylate and the (N), atom of the (-NH2) groups. The general formula was given for the prepared mixed ligand complexes as [M (Cur)(L-dopa)2 ]. M= Mn (II), Fe (II),Co(II),Ni(II),Cu (II), Zn(II), Cd(II) and Hg(II).The ligands and their metal complexes were screened for their antimicrobial activity klebsiella pneumonie,and Staphylococcus aureus, and Candida albicans. Metal chelates showed very good antimicrobial activity than their parent curcumin-and (L- dopa). We have given the general formula for the prepared mixed ligand complexes as [M (Cur)(L-dopa)2].M= Mn (II), Fe (II),Co(II) ,Ni(II),Cu (II), Zn(II), Cd(II) and Hg(II).The ligands and their metal complexes were screened for their antimicrobial activity klebsiella pneumonie,and Staphylococcus aureus, and Candida albicans. Metal chelates show very good antimicrobial activity than their parent Curcumin-and (L- dopa).

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“…A pronounced band around 1470 and 1502 cm -1 in the ligand (SMX) have shifted to lower frequency bands at 1404 and 1405 cm -1 , showing the participation of sulpha oxygen atoms in coordination. Moreso, strong bands around 3144 and 3372 cm -1 attributed to NH2 in the parent ligand but with bathochromic shifts to 3394-3396cm -1 in the metal complexes, suggesting the involvement of nitrogen atom in the coordination of metal complexes, therefore, predicting a bidentate coordinate dative bonding [18]. The presence of water was confirmed in the absorption bands around 754-755 cm -1 then, in the ligand with prominent bands around 3754-3760 cm -1 assigned to -OH group from the water of crystallization in the metal salt [19].…”

Section: Discussionmentioning

confidence: 97%

Synthesis, characterization and anti-microbial activities of mixed ligand complexes of sulphamethoxazole-urea with cobalt (II) and zinc (II) ions in water-methanol medium

Sulaiman Adeoye Olagboye

2022

GSC Biol. and Pharm. Sci.

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Novel mixed ligand metal complexes of Zinc (II) and Cobalt (II) were respectively synthesized with sulphamethoxazole-urea in a water-methanol medium by refluxing method and characterized gravimetrically (using Mohr’s method for chloride and sulfur determination); the purity of the complexes through melting point determination; the functional groups present by infrared spectroscopy. The results predicted the coordination of the metals to the ligand through the amide group and oxygen atom of the sulphamethoxazole-urea bidentate. Solubility tests revealed that metal complexes were soluble in dimethyl sulphoxide acetone and ethanol. The metal complexes synthesized were also screened for their activities against some bacteria (Xanthomonas sp, E. coli, B. aureus, P. syrugiae, Staphylococcus sp., Bacillus aureus, and P. aureus) and some fungi (S. rolfsil, C. indimutiaum, C. capsicia) using Agar Disc diffusion principle. The metal complexes of sulphamethoxazole (SMX) and mixed ligands show little sign of bacteria inhibition but are more effective on fungi. The results indicate that the mixed ligand metal complexes were more biologically active than the free ligand. The better biological activity resulted in the MLC of Zn.

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Synthesis, characterization, and antibacterial activity of some transition metals with the Schiff base N-(2-furanylmethylene)-3-aminodibenzofuran

Cited by 9 publications

References 1 publication

Green synthesis of nanosized N,N'-bis(1-naphthylidene)-4,4'-diaminodiphenylmethane and its metal (II) complexes and evaluation of their biological activity

Green synthesis of nanosized N,N'-bis(1-naphthylidene)-4,4'-diaminodiphenylmethane and its metal (II) complexes and evaluation of their biological activity

Preparation, Structural Characterization and Biological Activities of Curcumin-Metal(II)-L-3,4-dihydroxyphenylalanin (L-dopa) complexes

Synthesis, characterization and anti-microbial activities of mixed ligand complexes of sulphamethoxazole-urea with cobalt (II) and zinc (II) ions in water-methanol medium

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