Synthesis, Characterization and Antibacterial Activity of Some New 1,2,4- Triazole Schiff bases and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines

Sim, Kooi‐Mow; Chan, Pei-Qie; Boo, Xin-Lik; Heng, Ker-Sin; Lye, Kah-Whei; Teo, Kah-Cheng

doi:10.2174/1570178614666171129160503

Cited by 14 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sim et al [ 100 ] synthesized and screened pyrimidine linked 1,2,4-triazolo[3,4- b ][1,3,4]thiadiazines ( 132 ) for their antibacterial potential against B. subtilis , B. cereus , S. aureus , P. aeruginosa , S. typhimurium , and E. coli . Screening results indicated that compound having 4-flurophenyl ring 132f demonstrated moderate activity against P. aeruginosa with MIC = 62.5 μg ml −1 (Fig.…”

Section: Pharmacological Properties Of 124-triazolo[34- B ][134]thiadiazinesmentioning

confidence: 99%

Vision on Synthetic and Medicinal Facets of 1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine Scaffold

et al. 2022

View full text Add to dashboard Cite

The present review article strives to compile the latest synthetic approaches for the synthesis of triazolothiadiazine and its derivatives, along with their diverse pharmacological activities, viz. anticancer, antimicrobial, analgesic and anti-inflammatory, antioxidant, antiviral, enzyme inhibitors (carbonic anhydrase inhibitors, cholinesterase inhibitors, alkaline phosphatase inhibitors, anti-lipase activity, and aromatase inhibitors) and antitubercular agents. The review focuses particularly on the structure–activity relationship of biologically important 1,2,4-triazolo[3,4- b ][1,3,4]thiadiazines, which have profound importance in drug design, discovery and development. In silico pharmacokinetic and molecular modeling studies have also been summarized. It is hoped that this review article will be of help to researchers engaged in the development of new biologically active entities for the rational design and development of new target-oriented 1,2,4-triazolo[3,4- b ][1,3,4]thiadiazine-based drugs for the treatment of multifunctional diseases. Graphical Abstract

show abstract

Section: Pharmacological Properties Of 124-triazolo[34- B ][134]thiadiazinesmentioning

confidence: 99%