Synthesis, characterization and anti-breast cancer potential of an incensole acetate nanoemulsion from Catharanthus roseus essential oil; in silico, in vitro, and in vivo study

Nayila, Iffat; Sharif, Sumaira; Lodhi, Madeeha Shahzad; Rehman, Muhammad Fayyaz Ur; Aman, Farhana

doi:10.1039/d3ra06335f

Cited by 3 publications

(2 citation statements)

References 78 publications

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“…oxidative stress markers, proinflammatory cytokines, and tumor growth profiling in cancer-induced rats lend support to its anticancer properties [96], as shown in Figure 3. However, Vinblastine's adverse effects include bone marrow suppression (which causes deep ulcers), gastrointestinal toxicity, significant vesicant (blister-forming) activity, and extravasation damage.…”

Section: Catharanthus Roseusmentioning

confidence: 81%

“…In a rat model of DMBA-induced increased interleukin serum indicators, nanoemulsion treatment led to a significant improvement. Furthermore, the potential effects of IA biosynthesized nanoemulsion on biochemical parameters, oxidative stress markers, proinflammatory cytokines, and tumor growth profiling in cancer-induced rats lend support to its anticancer properties [96], as shown in Figure 3. However, Vinblastine's adverse effects include bone marrow suppression (which causes deep ulcers), gastrointestinal toxicity, significant vesicant (blister-forming) activity, and extravasation damage.…”

Section: Catharanthus Roseusmentioning

confidence: 83%

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Potential Anti-Tumorigenic Properties of Diverse Medicinal Plants against the Majority of Common Types of Cancer

Albahri,

Badran,

Abdel Baki

et al. 2024

Pharmaceuticals

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Globally, cancer is one of the primary causes of both morbidity and mortality. To prevent cancer from getting worse, more targeted and efficient treatment plans must be developed immediately. Recent research has demonstrated the benefits of natural products for several illnesses, and these products have played a significant role in the development of novel treatments whose bioactive components serve as both chemotherapeutic and chemo-preventive agents. Phytochemicals are naturally occurring molecules obtained from plants that have potential applications in both cancer therapy and the development of new medications. These phytochemicals function by regulating the molecular pathways connected to the onset and progression of cancer. Among the specific methods are immune system control, inducing cell cycle arrest and apoptosis, preventing proliferation, raising antioxidant status, and inactivating carcinogens. A thorough literature review was conducted using Google Scholar, PubMed, Scopus, Google Patent, Patent Scope, and US Patent to obtain the data. To provide an overview of the anticancer effects of several medicinal plants, including Annona muricata, Arctium lappa, Arum palaestinum, Cannabis sativa, Catharanthus roseus, Curcuma longa, Glycyrrhiza glabra, Hibiscus, Kalanchoe blossfeldiana, Moringa oleifera, Nerium oleander, Silybum marianum, Taraxacum officinale, Urtica dioica, Withania somnifera L., their availability, classification, active components, pharmacological activities, signaling mechanisms, and potential side effects against the most common cancer types were explored.

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Section: Catharanthus Roseusmentioning

confidence: 81%

Section: Catharanthus Roseusmentioning

confidence: 83%

Potential Anti-Tumorigenic Properties of Diverse Medicinal Plants against the Majority of Common Types of Cancer

Albahri,

Badran,

Abdel Baki

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

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Chemical profiling and quality evaluation of raw and vinegar‐processing frankincense by multiple UPLC‐MS/MS techniques

Li,

Wang,

Rao

et al. 2024

Phytochemical Analysis

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IntroductionFrankincense is used for analgesic, tumor‐suppressive, and anti‐inflammatory treatments in Traditional Chinese Medicine but poses toxicological concerns. Vinegar processing is a common technique used to reduce the toxicity of frankincense.ObjectiveThis study aimed to investigate the chemical composition and quality evaluation of raw and vinegar‐processing frankincense by multiple UPLC‐MS/MS techniques. Additionally, we purposed refining the vinegar processing technique and identifying potentially harmful ingredients in the raw frankincense.MethodologySub‐chronic oral toxicity studies were conducted on raw and vinegar‐processing frankincense in rats. The composition of frankincense was identified by UPLC‐Q‐TOF‐MS/MS. Chemometrics were used to differentiate between raw and vinegar‐processing frankincense. Potential chemical markers were identified by selecting differential components, which were further exactly determined by UPLC‐QQQ‐MS/MS. Moreover, the viability of the HepG2 cells of those components with reduced contents after vinegar processing was assessed.ResultsThe toxicity of raw frankincense is attenuated by vinegar processing, among which vinegar‐processing frankincense (R40) (herb weight: rice vinegar weight = 40:1) exhibited the lowest toxicity. A total of 83 components were identified from frankincense, including 40 triterpenoids, 37 diterpenoids, and 6 other types. The contents of six components decreased after vinegar‐processing, with the lowest levels in R40. Three components, specifically 3α‐acetoxy‐11‐keto‐β‐boswellic acid (AKBA), 3α‐acetoxy‐α‐boswellic acid (α‐ABA), and 3α‐acetoxy‐β‐boswellic acid (β‐ABA), inhibited the viability of HepG2 cells. The processing of frankincense with vinegar at a ratio of 40:1 could be an effective method of reducing the toxicity in raw frankincense.ConclusionOur research improves understanding of the toxic substance basis and facilitates future assessments of frankincense quality.

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Targeting the WWP1 gene with incensole acetate nanoemulsion: A novel therapeutic strategy for breast cancer

Nayila,

Sharif,

Lodhi

et al. 2024

South African Journal of Botany

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Synthesis, characterization and anti-breast cancer potential of an incensole acetate nanoemulsion from Catharanthus roseus essential oil; in silico, in vitro, and in vivo study

Abstract: The prospective activity of incensole acetate (IA) identified and isolated from Catharanthus roseus essential oil and the anticancer potential of an IA biosynthesized nanoemulsion against DMBA induced breast cancer markers was investigated.

Cited by 3 publications

References 78 publications

Potential Anti-Tumorigenic Properties of Diverse Medicinal Plants against the Majority of Common Types of Cancer

Potential Anti-Tumorigenic Properties of Diverse Medicinal Plants against the Majority of Common Types of Cancer

Chemical profiling and quality evaluation of raw and vinegar‐processing frankincense by multiple UPLC‐MS/MS techniques

Targeting the WWP1 gene with incensole acetate nanoemulsion: A novel therapeutic strategy for breast cancer

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