Synthesis, characterization and adsorption properties of alginate porous beads

Peretz, Sandu; Anghel, Dan F.; Vasilescu, Elena; Florea-Spiroiu, Manuela; Stoian, Cristina; Zgherea, Gheorghe

doi:10.1007/s00289-015-1459-4

Cited by 42 publications

(16 citation statements)

References 38 publications

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“…The two typical band of COO − were observed at 1593.88 cm −1 and 1405.85 cm −1 corresponding to the symmetrical and asymmetrical stretching vibrations, respectively (see spectrums B-D and E in Fig. 7) [12,23,[57][58][59]. In the blank calcium alginate microbeads spectrum, a broadband at 3361.32 cm −1 was observed attributed to water molecules (H 2 O).…”

Section: Optimal Factors For the Formulation Of Gallic Acid-loaded Camentioning

confidence: 95%

“…Alginate acid as a natural polysaccharide extracted from brown algae possesses many advantages compared to the various polymers adopted for elaborating hydrogel micro and nanobeads [12,[23][24][25][26][27][28][29]. The alginate macromolecule consists of chains of gluconic acid (G-block) and chains of mannuronic acid (M-block) and chains of mixed sequence of M-G-blocks.…”

Section: Introductionmentioning

confidence: 99%

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Optimization of gallic acid encapsulation in calcium alginate microbeads using Box-Behnken Experimental Design

et al. 2020

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The aim of this study was the optimization of the gallic acid (GA) encapsulation efficiency within calcium alginate microparticles by the ionotropic gelation technique, using Box-Behnken design for the surface methodology response. For this purpose, three independent variables were selected: sodium alginate concentration (X1), calcium chloride concentration (X2), and gallic acid concentrations (X3). The influence of each variable on the encapsulation efficiency was evaluated. The optimum conditions to reach maximum encapsulation efficiency were found to be: X1 = 30 g/l (3%, w/v), X2 = 21.63 g/l (2.163%, w/v) and X3 = 15 g/l (1.5%, w/v), respectively. The encapsulation efficiency was determined to be 42.8%. The obtained microbeads were further examined using differential scanning calorimetry (DSC) and Fourier transform infrared (ATR-FTIR), and the inclusion of gallic acid was confirmed. The gallic acid concentration (X3) is the statistically significant factor in the optimization process. In addition, no autoxidation of the gallic acid compound was observed in the formulated calcium alginate microbeads. Scanning electron microscope (SEM) analysis showed that the shape of the particle was spherical for all formulations and their surface is wrinkled. The release study of the gallic acid carried out in an aqueous medium at pH value 6.8, showed that the GA release pattern was fast for all systems studied (85% at 20 min), and the profile of the release was influenced by the size of the calcium alginate microbeads. The obtained results reveal that the calcium alginate microbeads prepared through the ionotropic gelation technique possess great prominent for gallic acid encapsulation as well as its liberation.

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Section: Optimal Factors For the Formulation Of Gallic Acid-loaded Camentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Optimization of gallic acid encapsulation in calcium alginate microbeads using Box-Behnken Experimental Design

et al. 2020

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“…In the case of sodium alginate polymer, the spectrum reveals the presence of a broad vibrational band located at 3268 cm −1 , which is attributed to the stretching of the O-H function. e symmetrical and asymmetrical stretching vibrations of COO − groups were observed at 1593.88 cm −1 and 1405.85 cm −1 , respectively (Figure 3(b)) [6,[26][27][28][29].…”

Section: Attenuated Total Reflection Fourier Transform Infraredmentioning

confidence: 97%

Influence of Sodium Alginate Concentration on Microcapsules Properties Foreseeing the Protection and Controlled Release of Bioactive Substances

Brahmi

Berraaouan

Ed-Daoui

et al. 2021

Journal of Chemistry

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To understand the abilities of Ca-alginate microcapsules and their specific applications in different fields, it is necessary to determine the physicochemical and structural properties of those formulated microcapsules. In this work, we aimed to study the effect of alginate concentration in the improvement of the encapsulation efficiency (EE) and on the release of phenolic and flavonoid substances. The relationship between the structure of the encapsulated bioactive substance and Ca-alginate network and their effect on the EE and release kinetics have been investigated. The incorporation, structure, morphology, and phase properties of all elaborated materials were characterized by UV-spectroscopy, Fourier transform infrared (ATR-FTIR), scanning electron microscope (SEM), and X-ray diffraction (DRX). The results indicate that increasing the polymer concentration increases the EE and decreases the loading capacity (LC), whereas the effect of alginate polymer concentration on the release was not observed. The release study of bioactive substances showed that the release kinetics is relatively dependent on the structure and the physicochemical characteristics of the bioactive substance, which became clear when the encapsulated compounds were released from the core of calcium alginate microcapsules. Thus, it could be concluded that the pores size of the Ca-alginate network is smaller than the volume of the crocin molecule (2794.926 Å3) and higher than the volume of the gallic acid molecule (527.659 Å3). For the same microcapsules system, the release mechanism is affected by the structure and physicochemical properties of the encapsulated molecules.

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“…Alginate is a linear non branched polysaccharide obtained from brown marine algae and it mainly consists on linear polymeric chains from α‐l‐guluronic acid and β‐D‐mannuronic acid residues joined by 1,4‐glycosidic linkages . One of the most relevant features of alginate polymers is their ability to form gel structures by reaction with divalent cations such as Ca 2+ . Typical alginate microcapsules can be obtained by extrusion of the alginate‐containing solution in the form of drops over the crosslinking solution with divalent cations such as Ca 2+ , Sr 2+ , Ba 2+ …”

Section: Introductionmentioning

confidence: 99%

Development and characterization of bioactive alginate microcapsules with cedarwood essential oil

Ferrándiz

López

Franco

et al. 2017

Flavour & Fragrance J

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In this work, sodium alginate microcapsules containing cedarwood essential oil (CWO) for uses in anti‐acne tonic were prepared by ionic gelification of alginate with calcium chloride (CaCl2) and subsequent addition of glutaraldehyde to improve the crosslinking degree. Alginate microcapsules with cedarwood essential oil were obtained in an encapsulator with a 600 μm nozzle using different alginate concentrations (1, 3 and 4% w/v) , and different compositions of the coagulation solution with CaCl2 concentrations of 0.1, 0.25 and 0.5 M, and addition of glutaraldehyde at two concentrations: 12.5% and 50% (0.1 g L−1 and 10 g L−1, respectively). The effect of alginate concentration was followed by viscosimetry and the influence of the CaCl2 concentration and presence of glutaraldehyde on the microcapsules' shape as well as the total content on encapsulated cedarwood essential oil were evaluated by means of stereoscopic magnifying glass, scanning electron microscopy (SEM) and UV–vis spectrophotometry. Results show that proper shape formation is obtained for an alginate concentration of 3% w/v. With regard to the total encapsulated cedarwood oil, as the CaCl2 concentration in the gelifying‐coagulating solution increases the efficiency of the encapsulated oil. Best results in terms of micro‐bead shape and total amount of encapsulated oil were obtained for a CaCl2 concentration of 0.5 M without glutaraldehyde with a maximum encapsulation of 177.2 mg per gram of microcapsule.

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Synthesis, characterization and adsorption properties of alginate porous beads

Cited by 42 publications

References 38 publications

Optimization of gallic acid encapsulation in calcium alginate microbeads using Box-Behnken Experimental Design

Optimization of gallic acid encapsulation in calcium alginate microbeads using Box-Behnken Experimental Design

Influence of Sodium Alginate Concentration on Microcapsules Properties Foreseeing the Protection and Controlled Release of Bioactive Substances

Development and characterization of bioactive alginate microcapsules with cedarwood essential oil

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