Synthesis, characterisation, cytotoxicity, DNA binding and antimicrobial studies of binary and ternary metal complexes of Co (II)

Pilli, Jyothi; Koppu, Suneetha; Sumalatha, V.; Ushaiah, B.; Kumari, C. Gyana

doi:10.1016/j.inoche.2019.107590

Cited by 13 publications

(2 citation statements)

References 20 publications

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“…The Cr(III) complex displayed three absorption bands at (λ max =1020, 936, and 500) nm was due to 4 A2g 4 T2g , 4 A2g 4 T1g(F), and 4 A2g 4 T1g(P) transitions, respectively indicating octahedral geometry which is supported by its observed magnetic moment of 3.82 B.M. and its (d 3 ) configuration [19]. The important ligand field parameters were calculated Dq= 980 cm -1 , B= 680 cm -1 , β=0.74, and v2/v1=1.09.…”

Section: Magnetic Susceptibility and Uv-visible Spectroscopymentioning

confidence: 85%

New aroyl heterocyclic (E)-N′-((2-hydroxynaphthalen-1-yl)methylene)-4-oxopiperidine-1-carbohydrazide and its metal complexes: synthesis, spectroscopic, thermal, DFT, molecular docking and antimicrobial studies

Dongare,

Aswar

2023

Res Chem Intermed

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In order to resist the growth of human pathogenic microorganisms, we have synthesized a new N-heterocyclic hydrazone ligand of (E)-N'-(2-hydroxynaphthalen-1-yl)methylene-4-oxopiperidine-1-carbohydrazide (H2L) from the condensation reaction of 4-oxo-1-carbopiperidone hydrazide and 2-hydroxy-1-naphthaldehyde. The ligand reacted with metal salt of (M(II/III).Cl2).nH2O formed the two types of complexes [M(III)C17H19N3O5Cl] and [M(II)C17H20N3O5Cl] adopted octahedral geometry; where M=Cr(III), Fe(III), Mn(II), Co(II), Ni(II), Cu(II) ion. The ligand was thoroughly characterized by elemental analysis, FT−IR, UV−Vis, NMR ( 1 H, 13 C), HR-mass spectroscopy. Furthermore, the structural properties of metal complexes have been established on the basis of elemental analysis, UV-vis spectra, molar conductivity, magnetic susceptibility, ESR, TG-DTA analysis. The ligand behaves dibasic, linkages via phenolic-O, azomethine-N, enolic-O atoms in metal (III) complexes and monobasic in metal(II) complexes. The decomposition pattern were ascertained by thermal analysis, and kinetics accountability from Coats-Redfern relation. The compounds were excited at λex = 380 nm and observed good emission intensity at λem = λ527-533 nm. The surface morphology of ligand was distinct from complex proven an imaging by SEM analysis. The molecular geometry optimization, and quantum chemical properties have been retrieved from DFT. ADMET score have been predicted as a drug-likeness prospect from admetSAR method. The molecular docking outcomes displayed the good binding score of ligand with Adenylate kinase, Peptide deformylase (bacterial enzyme) and DNA polymerase (fungal enzyme).The in vitro antimicrobial potency of ligand and its complexes were showed the promising activity against the bacterial colony (Escherichia coli, Salmonella typhi, Staphylococcus aureus, Bacillus substilis), and fungal colony (Candida albicans, Aspergillus niger).

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Section: Magnetic Susceptibility and Uv-visible Spectroscopymentioning

confidence: 85%

New aroyl heterocyclic (E)-N′-((2-hydroxynaphthalen-1-yl)methylene)-4-oxopiperidine-1-carbohydrazide and its metal complexes: synthesis, spectroscopic, thermal, DFT, molecular docking and antimicrobial studies

Dongare,

Aswar

2023

Res Chem Intermed

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“…The significant decrease in absorbance (hypochromism) of complex 1 in the presence of DNA without any shift suggests that 1 binds avidly with ctDNA via groove-binding mode. The presence of hypochromism (22%) may indicate the DNA complex stabilization due to π-π* stacking occurs between the aromatic naphthalene rings, which approaches partial intercalation of the base moiety through non-covalent interaction [64]. The binding strength of complex 1 was quantitatively determined by calculating the intrinsic binding constant Kb, and it was found to be 2.38 × 10 5 M -1 .…”

Section: Absorption Titrationsmentioning

confidence: 99%

Depicting the DNA Binding and Cytotoxicity Studies against Human Colorectal Cancer of Aquabis (1-Formyl-2-Naphtholato-k2O,O′) Copper(II): A Biophysical and Molecular Docking Perspective

Alolayqi¹,

Afzal²,

Alarifi³

et al. 2021

Crystals

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In this study, we attempted to examine the biological activity of the copper(II)–based small molecule aquabis (1-formyl-2-naphtholato-k2O,O′)copper(II) (1) against colon cancer. The characterization of complex 1 was established by analytical and spectral methods in accordance with the single-crystal X-ray results. A monomeric unit of complex 1 exists in an O4 (H2O) coordination environment with slightly distorted square pyramidal geometry (τ = ~0.1). The interaction of complex 1 with calf thymus DNA (ctDNA) was determined by employing various biophysical techniques, which revealed that complex 1 binds to ctDNA at the minor groove with a binding constant of 2.38 × 105 M–1. The cytotoxicity of complex 1 towards human colorectal cell line (HCT116) was evaluated by the MTT assay, which showed an IC50 value of 11.6 μM after treatment with complex 1 for 24 h. Furthermore, the apoptotic effect induced by complex 1 was validated by DNA fragmentation pattern, which clarified that apoptosis might be regulated through the mitochondrial-mediated production of reactive oxygen species (ROS) causing DNA damage pathway. Additionally, molecular docking was also carried out to confirm the recognition of complex 1 at the minor groove.

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Synthesis and Characterization of Metal Complexes [M(L)(Im)]NO₃, In Vitro DNA/BSA Binding Behavior and Cytotoxicity on HepG2 Cancer Cells

Alroba,

Aazam,

Zaki

2024

ChemistrySelect

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A new ligand (HL) was prepared from heterocyclic 8‐Hydroxy‐2‐quinolinecarboxaldehyde and 2‐Aminobenzophenone in one pot synthesis. The metal complexes of the types [Zn(L)(Im)]NO3 (1), [Cu(L)(Im)]NO3 (2) and [Co(L)(Im)]NO3 (3) were prepared by adopting HL and Imidazole under refluxing conditions. The HL and complexes 1–3, were characterized by CHN elemental analysis and spectroscopic methods 1H NMR, 13C NMR, FT‐IR, ToF Mass. The spectroscopic studies suggest square pyramidal geometry in all complexes. The interaction of ligand and complexes with DNA and BSA was conducted by UV‐vis absorption and fluorescence spectroscopy. The Kb value of 2.17×104 M−1 for complex 2 is the highest depicting its greater binding propensity with DNA. Similarly, in BSA binding studies, complex 2 shows greater binding potential in the hydrophobic core probably near the Trp 212 in the subdomain IIA. Furthermore, the complex 2 shows excellent cytotoxicity on HepG2 cancer cells with IC50=74.05±0.69 μM. In the cell cycle analysis of HepG2 cells, it has been observed that complex 2 arrests the cell proliferation in the G1/S phase. Annexin V‐based flow cytometry analysis further indicated 6‐fold apoptotic cell death by complex 2 in the experiment along with non‐specific necrosis cell death.

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Synthesis, characterisation, cytotoxicity, DNA binding and antimicrobial studies of binary and ternary metal complexes of Co (II)

Cited by 13 publications

References 20 publications

New aroyl heterocyclic (E)-N′-((2-hydroxynaphthalen-1-yl)methylene)-4-oxopiperidine-1-carbohydrazide and its metal complexes: synthesis, spectroscopic, thermal, DFT, molecular docking and antimicrobial studies

New aroyl heterocyclic (E)-N′-((2-hydroxynaphthalen-1-yl)methylene)-4-oxopiperidine-1-carbohydrazide and its metal complexes: synthesis, spectroscopic, thermal, DFT, molecular docking and antimicrobial studies

Depicting the DNA Binding and Cytotoxicity Studies against Human Colorectal Cancer of Aquabis (1-Formyl-2-Naphtholato-k2O,O′) Copper(II): A Biophysical and Molecular Docking Perspective

Synthesis and Characterization of Metal Complexes [M(L)(Im)]NO₃, In Vitro DNA/BSA Binding Behavior and Cytotoxicity on HepG2 Cancer Cells

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Synthesis, characterisation, cytotoxicity, DNA binding and antimicrobial studies of binary and ternary metal complexes of Co (II)

Cited by 13 publications

References 20 publications

New aroyl heterocyclic (E)-N′-((2-hydroxynaphthalen-1-yl)methylene)-4-oxopiperidine-1-carbohydrazide and its metal complexes: synthesis, spectroscopic, thermal, DFT, molecular docking and antimicrobial studies

New aroyl heterocyclic (E)-N′-((2-hydroxynaphthalen-1-yl)methylene)-4-oxopiperidine-1-carbohydrazide and its metal complexes: synthesis, spectroscopic, thermal, DFT, molecular docking and antimicrobial studies

Depicting the DNA Binding and Cytotoxicity Studies against Human Colorectal Cancer of Aquabis (1-Formyl-2-Naphtholato-k2O,O′) Copper(II): A Biophysical and Molecular Docking Perspective

Synthesis and Characterization of Metal Complexes [M(L)(Im)]NO3, In Vitro DNA/BSA Binding Behavior and Cytotoxicity on HepG2 Cancer Cells

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Synthesis and Characterization of Metal Complexes [M(L)(Im)]NO₃, In Vitro DNA/BSA Binding Behavior and Cytotoxicity on HepG2 Cancer Cells