Synthesis, characterisation and evaluation of oxadiazole as promising anticancer agent

Abstract

A unique series oxadiazoles were synthesized by cyclization of benzophenone hydrazide, followed by the nucleophillic alkylation of heterocyclic scaffold. Synthesized title compounds were characterized by the FT-IR, LCMS and NMR spectral techniques. The newly synthesized compounds were screened for the anticancer activity. IC 50 values of the 7h observed for in-vitro anti-cancer activities were 112.6 µg/ml and 126.7 µg/ml, against the MCF-7 and KB cell lines respectively. Most active compounds were found to be less toxic, which were determined by MTT assay method with normal cell line (L292). Biological screening of the synthesized series of compounds reveals that, Compound 7h was the potent molecule.Electronic supplementary material The online version of this article (https ://doi.org/10.1007/s4245 2-020-2511-z) contains supplementary material, which is available to authorized users. * S. V. Mamatha, mamatha.zh32@yahoo.com |

Design, Synthesis and Pharmacological Evaluation of Some C₃ Heterocyclic-Substituted Ciprofloxacin Derivatives as Chimeric Antitubercular Agents

“…25) Condensation of acid hydrazide (3) with N-benzylisatins in presence of ethanol and acetic acid yielded the isatin sub- stituted ciprofloxacin derivatives (4-6). 26) In another two different experimental setups, reaction of ciprofloxacin acid hydrazide (3) with phthalic anhydride, 27) potassium hydroxide and carbon disulfide 28) produced compounds (7) and (8), respectively (Chart 1).…”