Synthesis, Characterisation and DFT Studies of Stigmasterol Mediated Silver Nanoparticles and Their Anticancer Activity

Kanagamani, Krishnaswamy; Muthukrishnan, P.; Ilayaraja, M.; Shankar, K. Ravi; Kathiresan, Ayyasami

doi:10.1007/s10904-017-0721-7

Cited by 16 publications

(7 citation statements)

References 31 publications

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“…In addition, one of the most abundant plant sterols, stigmasterol, was reported to facilitate Ag ions reduction [ 39 ], used completely during methanol-mediated and methanol-hexane-mediated NS synthesis. The presence of stigmasterol has also been detected in acetone-based extract, although its participation during the reaction is not significant.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, one of the most abundant plant sterols, stigmasterol, was reported to facilitate Ag ions reduction [39], used completely during methanol-mediated and methanol-hexane-mediated NS synthesis. The presence of stigmasterol has also been detected The same role can be attributed to other alkaloids, caffeoylquinic acid, and 1,4-Dicaffeoylquinic acid derivatives, having a well-known antioxidant activity [37].…”

Section: Green Chemistry and Synthesis Of Nsmentioning

confidence: 99%

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Photodegradation of Biohazardous Dye Brilliant Blue R Using Organometallic Silver Nanoparticles Synthesized through a Green Chemistry Method

Sidorowicz

Szymański

Rybka

2021

Biology

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Nowadays, nanostructures having tremendous chemical and physical properties are gaining attention in the biomedical industry. However, when they are prepared through classical methods (physical and chemical), they are often non-biocompatible and toxic. Considering the mentioned factors, in this research, organometallic silver nanostructures (OMAgNs) have been prepared by the green chemistry method using the acetone, methanol, and methanol-hexane-based extracts of the medicinally important plant Cichorium intybus. Secondary metabolites from C. intybus can be used as an alternative to synthetic reagents at an industrial scale to manufacture biosafe and economical nanostructures with enhanced physicochemical parameters. Prepared nanostructures were characterized using SEM, XRD, FTIR, TGA, UV, and zeta potential measurement. SEM analysis revealed different shapes of OMAgNs, prepared with various extracts. XRD analysis showed the crystallinity of the nanostructures. FTIR spectroscopy helped to identify groups of compounds present in the extracts and used for the OMAgNs synthesis. Out of the three tested OMAgNs, those prepared with methanol extract were selected due to the highest obtained yield and stability (highest negative zeta potential) and were tested as a cost-efficient and active agent to photodegrade organic pollutant, Brilliant Blue R, using energy from sunlight. A decrease in UV-VIS absorbance confirmed the rapid degradation of the dye.

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Section: Discussionmentioning

confidence: 99%

“…In addition, one of the most abundant plant sterols, stigmasterol, was reported to facilitate Ag ions reduction [39], used completely during methanol-mediated and methanol-hexane-mediated NS synthesis. The presence of stigmasterol has also been detected The same role can be attributed to other alkaloids, caffeoylquinic acid, and 1,4-Dicaffeoylquinic acid derivatives, having a well-known antioxidant activity [37].…”

Section: Green Chemistry and Synthesis Of Nsmentioning

confidence: 99%

Photodegradation of Biohazardous Dye Brilliant Blue R Using Organometallic Silver Nanoparticles Synthesized through a Green Chemistry Method

Sidorowicz

Szymański

Rybka

2021

Biology

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“…In the last twenty years, the frontier orbitals began to play a pivotal role in the medicinal chemistry field; the studies of highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) have allowed the understanding of several biological activities, such as antimicrobial [ 62 , 63 , 64 , 65 ], anticancer [ 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ], antifungal [ 74 , 75 , 76 ], and cytotoxicity [ 77 , 78 , 79 , 80 ]. More recently, the shape of frontier orbitals has been used to differentiate between active and inactive compounds against a specific disease [ 81 , 82 ].…”

Section: Resultsmentioning

confidence: 99%

In Silico Screening of the DrugBank Database to Search for Possible Drugs against SARS-CoV-2

2021

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Coronavirus desease 2019 (COVID-19) is responsible for more than 1.80 M deaths worldwide. A Quantitative Structure-Activity Relationships (QSAR) model is developed based on experimental pIC50 values reported for a structurally diverse dataset. A robust model with only five descriptors is found, with values of R2 = 0.897, Q2LOO = 0.854, and Q2ext = 0.876 and complying with all the parameters established in the validation Tropsha’s test. The analysis of the applicability domain (AD) reveals coverage of about 90% for the external test set. Docking and molecular dynamic analysis are performed on the three most relevant biological targets for SARS-CoV-2: main protease, papain-like protease, and RNA-dependent RNA polymerase. A screening of the DrugBank database is executed, predicting the pIC50 value of 6664 drugs, which are IN the AD of the model (coverage = 79%). Fifty-seven possible potent anti-COVID-19 candidates with pIC50 values > 6.6 are identified, and based on a pharmacophore modelling analysis, four compounds of this set can be suggested as potent candidates to be potential inhibitors of SARS-CoV-2. Finally, the biological activity of the compounds was related to the frontier molecular orbitals shapes.

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“…The peaks at 2θ= 32.29°, 38.27°, 44.48°, and 64.53°, correspond to the crystalline plates (111), ( 200) and (220) of Ag phase with FCC structure, respectively. It should be noted that the diffraction peak at 32.29° is due to the crystalline and amorphous organic phase [36]. The average particle size of AgNPs estimated to be about 18 nm by consideration of the average value of (111), ( 200) and (220) peaks in Scherrer equation [37].…”

Section: Xrd Studiesmentioning

confidence: 99%

“…The reaction mechanism can be explained employing molecular orbital theory. The reaction between two molecules takes place if the electronic repulsion by charge attraction or orbital overlap is overcome by the amount of activation energy [36,38]. This energy is defined by the minimum difference of energy between the HOMO energy of a molecule with the LUMO energy of the other.…”

Section: Quantum Chemical Study For the Reduction Of Agnpsmentioning

confidence: 99%

Green Synthesis of Ag Nanoparticles by Methadone and their Cytotoxicity against Human Breast Cancer Cells

2021

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Recently, the preparation of silver nanoparticles (AgNPs) by green technique has improved due to their fundamental applications in medicine. In this study, methadone syrup (ME) was used for the preparation of AgNPs as a reducing and stabilizing agent with the aim of in vitro cytotoxicity effect against the human breast cancer cells. The characteristics of prepared particles are investigated by transmission electron microscopy (TEM), environmental scanning electron microscopy (ESEM), energy-dispersive X-ray spectroscopy (EDS), dynamic light scattering (DLS), UV-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction studies (XRD). The AgNPs (about 18 nm) were synthesized in a spherical shape and uniform distribution. The mechanism of ME through the synthesis has been proposed based on FT-IR analysis and density functional theory (DFT). To investigate the cytotoxicity of prepared AgNPs by ME, 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used in the range of 0-100 μg/mL. As a function of its dosage, the green synthetic AgNPs showed antiproliferation activity against MDA-MB-468 cells respect to ME. The results demonstrated the feasibility of producing AgNPs in a simple, rapid, and green manner using ME, which has an important function in inhibiting the growth of breast cancer cells.

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Synthesis, Characterisation and DFT Studies of Stigmasterol Mediated Silver Nanoparticles and Their Anticancer Activity

Cited by 16 publications

References 31 publications

Photodegradation of Biohazardous Dye Brilliant Blue R Using Organometallic Silver Nanoparticles Synthesized through a Green Chemistry Method

Photodegradation of Biohazardous Dye Brilliant Blue R Using Organometallic Silver Nanoparticles Synthesized through a Green Chemistry Method

In Silico Screening of the DrugBank Database to Search for Possible Drugs against SARS-CoV-2

Green Synthesis of Ag Nanoparticles by Methadone and their Cytotoxicity against Human Breast Cancer Cells

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