Synthesis, Characterisation and Cytotoxicity of Polyoxometalate/Carboxymethyl Chitosan Nanocomposites

Abstract

Chitosan and its derivates continue to attract considerable research interest as effective drug carriers with good biocompatibility and high cellular uptake rates. We used these versatile features to tap the considerable biomedical potential of polyoxometalates (POMs) through their encapsulation into a carboxymethyl chitosan (CMC) matrix. The nanocapsules were prepared by ionic gelification with Ca(2+); their size distribution ranges from 60 to 150 nm. Because [Co(4)(H(2)O)(2)(PW(9)O(34))(2)](10-) is well known for its manifold properties, such as antiviral activity, it was selected as a model POM. The resulting composites were characterised with a wide range of analytical methods, which pointed to quantitative encapsulation of intact POMs within the CMC matrix. We studied the biocompatibility of the POM/CMC nanocomposites on HeLa cells through MTT and proliferation assays. Even after prolonged incubation times at high concentrations, the composites did not display cytotoxicity, thereby drastically reducing the side effects of the pristine POMs. This opens up new avenues for designing novel inorganic drug prototypes from bioactive POMs.

FABRICATION OF NOVEL ANTICANCER POLYOXOMETALATE [CoW11O39(CpTi)]7- -CHITOSAN NANO-COMPOSITE, ITS TOXICITY REDUCTION AND SUSTAINED RELEASE

“…This may be credited due to the formation of a complex by CSYC100 with thermally stable CoW11CpTi having lesser degradation as those are heavy metal salts similar results are also reported by Geisberger et al [3].…”

“…POMs have gained tremendous attention because of their mutable uses in the areas of novel drug development, material sciences, and in industrial catalyst [1]. The use of POMs in latent applications for human medicine is growing exponentially and are recently published in the literatures [2,3]. The toxicity due to the presence of metal ions is the major drawback of these precious medicinal molecules.…”

Renewable chitin from marine sponge as a thermostable biological template for hydrothermal synthesis of hematite nanospheres using principles of extreme biomimetics

“…A broad variety of reactions related to hydrothermal synthesis can be performed in vitro. This feature is also promising for chitin surface metallization, which normally requires temperatures up to 300 °C [29] and pH between 1 and 14 [30]. It is important to note that Extreme Biomimetics based on a combination of hydrothermal synthesis and utilization of morphologically defined 3D chitin structures perfectly aligns with green chemistry concepts [31][32][33][34].…”

The Anderson–Evans polyoxometalate: From inorganic building blocks via hybrid organic–inorganic structures to tomorrows “Bio-POM”

“…The isopolyanions lack heteroatoms resulting in an increased instability compared with heteropolyanions. The metal-oxide framework in heteropolyanions contains a templating heteroatom/heteropolyanion and has been in focus due to the great structural diversity that they bring, including the Keggin [XM 12 O 40 ] n- [2], Dawson [XM 18 O 62 ] n- [3] and Anderson-Evans archetypes [XM 6 O 24 ] n- [4,5]. The possibility to attach organic ligands [6] further contributes to the diversity of POM structures allowing the combination of inorganic POMs with specific organic functionalities and thus giving rise to new hybrid compounds [7].…”