Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with CoIII, NiII, CuII and ZnII

Holló, Berta Barta; Magyari, József; Živković-Radovanović, Vukosava; Vučković, Gordana; Tomić, Zoran D.; Szilágyi, Imre Miklós; Pokol, György; Szécsényi, Katalin Mészáros

doi:10.1016/j.poly.2014.03.007

Cited by 38 publications

(27 citation statements)

References 30 publications

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“…Therefore thermal analysis is a common part of characterizing compounds with biological activity [20,21,22,23,24,25]. Thermoanalytical methods provide important information on the thermal stability, polymorphic forms or structural changes [26,27,28], and purity of potential new drugs [29,30,31,32]. In continuation of our earlier work on synthesis, physical and chemical characterization of iron(II) complexes with amine ligands [33] in this paper Pt(II) coordination compounds with different amine ligands are described.…”

Section: Introductionmentioning

confidence: 93%

Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

Holló

Szilágyi

Várhelyi

et al. 2016

J Therm Anal Calorim

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Three complexes of general formula PtCl 2 R 2 were synthesized, where R is the amine ligand with aromatic substituents. Coordination compounds [Pt(an) 2 Cl 2 ] (1), [Pt(pa) 2 Cl 2 ] (2) and [Pt(aph) 2 Cl 2 ] (3), where an is 2-aminonaphtalene, pa is 2-pyrimidinamine and aph is 4-anilinophenol, were characterized by on-line coupled TG/DTA-MS, powder XRD and spectroscopic techniques (FTIR, ESI-MS and NMR), and tested against selected Gram(+) and Gram(-) bacteria. The thermal data show that all three compounds contain lattice or absorbed water, and the stability of the anhydrous compounds in nitrogen decreases in the order 2 > 1 > 3. Above 200 °C, the complexes loose characteristic fragments of their ligands. The spectroscopic data are in accordance with the thermal properties of the samples and prove their composition. The compounds are more effective inhibitors of Gram(+) than Gram(−) bacteria.

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Section: Introductionmentioning

confidence: 93%

Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

Holló

Szilágyi

Várhelyi

et al. 2016

J Therm Anal Calorim

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“…There are additional two binuclear complexes, 23,25 both with Co(III) metal centres and have, as well as Co(II) binuclear complexes, different coordination modes than that presented in 1. Recently, we have reported the crystal structure of a Co(III) complex 10 with the same donor set and very similar ligand to Hp 2 DAP as in 1, but in that case the complex molecule crystallized as discrete mononuclear units. A comparison of structural data for all 150 structures extracted from CSD also showed that complex 1, along with some Ni complexes 26a-d form one of the shortest M-N2 bonds in transition metal complexes with DAP derivatives.…”

Section: Synthesis Of Compoundsmentioning

confidence: 99%

“…A similar effect was observed in the case of a Zn(II) complex with bis(phthalazine-1hydrazone)-2,6-diacetylpyridine. 10…”

Section: Thermal Data For Hp 2 Dap and 1-4mentioning

confidence: 99%

Coordination compounds of a hydrazone derivative with Co(iii), Ni(ii), Cu(ii) and Zn(ii): synthesis, characterization, reactivity assessment and biological evaluation

et al. 2016

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“…For applications of hydrazones in supramolecular chemistry, see: Su & Aprahamian (2014). For biological applications of hydrazones and derivatives, see: Nair et al (2014); Prasanna & Kumar (2013); Holló et al (2014). For the synthesis of related compounds, see: Bessy et al (2006 Table 1 Hydrogen-bond geometry (Å , ).…”

Section: Related Literaturementioning

confidence: 99%

Crystal structure ofN′-[(E)-3,5-dichloro-2-hydroxybenzylidene]-4-nitrobenzohydrazide dimethylformamide monosolvate

et al. 2015

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In the title compound, C14H9Cl2N3O4·C3H7NO, the hydrazone molecule adopts an E conformation with respect to azomethine bond, and the dihedral angle between the two aromatic rings [8.96 (11)°] shows that the rings are almost co-planar. The planar conformation of the molecule is stabilized by the intramolecular O—H⋯N hydrogen bond involving the OH group and azomethine N atom. The azomethine and keto bond distances [1.269 (2) and 1.210 (2) Å, respectively] are very close to the formal C=N and C=O bond lengths. The dimethylformamide solvent molecule is connected to the hydrazone NH group via an N—H⋯O hydrogen bond. In the crystal, non-classical C—H⋯O and C—H⋯Cl hydrogen bonds link the molecules into chains along [322]. A supramolecular three-dimensional architecture is created by weak C—Cl⋯π [4.163 (3) Å, 83.26 (9)°] and π–π [centroid–centroid distance = 4.0395 (14) Å] interactions.

show abstract

Synthesis, characterisation and antimicrobial activity of bis(phthalazine-1-hydrazone)-2,6-diacetylpyridine and its complexes with CoIII, NiII, CuII and ZnII

Cited by 38 publications

References 30 publications

Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

Coordination compounds of a hydrazone derivative with Co(iii), Ni(ii), Cu(ii) and Zn(ii): synthesis, characterization, reactivity assessment and biological evaluation

Crystal structure ofN′-[(E)-3,5-dichloro-2-hydroxybenzylidene]-4-nitrobenzohydrazide dimethylformamide monosolvate

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