Synthesis, characterisation and antimicrobial activity of new benzo[a]phenoxazine based fluorophores

Novel Nile Blue Analogue Stains Yeast Vacuolar Membrane, Endoplasmic Reticulum, and Lipid Droplets, Inducing Cell Death through Vacuole Membrane Permeabilization

“…In previous work in our laboratory, we found that several newly synthetized fluorescent compounds derived from benzo[a]phenoxazine displayed antiproliferative activity against S. cerevisiae, used as a model eukaryotic organism, and that minor changes in substituents of the benzo[a]phenoxazine nucleus drastically influenced their activity, with MIC values ranging from 3.75 μM to over 400 μM, as well as their intracellular staining patterns [7,13,14,26,27,56]. Here, we found that one of these compounds, BaP1, induced a regulated cell death process and uncovered its mode of action to unveil its potential for pharmacological applications.…”

“…Phenoxazine derivatives are long wavelength fluorescent dyes of great importance as probes since they absorb and emit fluorescence in the 600-900 nm region of the spectrum where there is minimum interference with the biological molecules' autofluorescence [1][2][3][4][5][6]. They have been used in the covalent labeling of amino acids and proteins and in the non-covalent labeling of nucleic acids in various contexts such as blotting experiments, gel electrophoresis, and living cell assays [7][8][9][10][11].…”

Investigation of 3d-transition metal acetates in the oxidation of substituted dioxolene and phenols

“…Phenoxazinone containing compounds are also receiving increasing attention for various industrial applications viz. as antifungal and antimicrobial agents, dyes [164] and for the development of fluorescent probes for the detection of hydroxy radicals and live cell imaging [130,[165][166].…”

Synthesis, photophysical characterisation and photostability studies of NIR probes with aliphatic, aromatic and chlorinated terminals in 5- and 9-amino positions of benzo[ a ]phenoxazines

“…Considering the importance and as a continuation of our current research interest towards the design, synthesis and application of NB derivatives with different substituents [15][16][17][18][19][20][21][22][23][24][25], the present work is focused in the preparation of a new set of benzo[a]phenoxazinium chlorides with aliphatic, aromatic and chlorinated terminals in 5-and 9-amino positions of the heteroaromatic system. The photophysical behaviour of these compounds in anhydrous ethanol and in aqueous solutions was investigated along with photostability studies in water and in biological medium.…”