Synthesis Characterisation and Antimicrobial Activity of N-(2-Chloroquinolin-3-yl)methylene)- isonicotinohydrazide

Abstract

A series of novel N′-(2-chloro-substituted quinolin-3-yl)methylene)isonicotinohydrazide (3a-h) were prepared by condensation of 2-chloro-3-formylquinoline (1a-h) with isonicotinohydrazide (2) in the presence of catalytic quantity of acetic acid in methanol under reflux in good yield. Newly synthesized compounds were characterized by IR, 1 H NMR and mass. The newly synthesized compound (3a-h) has been screened for their antibacterial and antifungal activities. All compounds exhibited significant antibacterial and antifungal activity.