Synthesis by Wet Chemical Method of Different Phases of Apatites Applying Ultrasound

Rodriguez-Chanfrau, Jorge E.; Pelizaro, Thales A. Garcia; Silva, Ricardo Moutinho da; Tolaba, Angel G.; Pizoni, Elizabeth; Veranes-Pantoja, Yaymarilis; Guastaldi, Antônio Carlos

doi:10.1166/jbns.2018.1502

Cited by 5 publications

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“…Synthesis of calcium phosphate. Amorphous calcium phosphate (ACP), tricalcium phosphate (TCP) and octacalcium phosphate (OCP) were synthesized by applying the wet chemical method according to Rodriguez-Chanfrau et al [17] with the following modifications. In cases of synthesis ACP and OCP at the end of the reaction, the suspension was filtered and dried by vacuum freeze-drying process.…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of the influence of microwaves radiation on a biomaterial composed of three phases of calcium phosphates

2020

Biointerface Res Appl Chem

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The chemical similarity with the bone components that calcium phosphates present have been the fundamental cause of their use as biomaterials in the regeneration processes, presenting good biocompatibility, bioactivity and osteoconductivity. Among the biomaterials studied from calcium phosphates, there are multiphase biomaterials, which are those that contain two or more phases of calcium phosphates in their composition. These mixtures improve the chemical-physical and biological properties of these materials. The use of biomaterials in the regeneration process requires previously eliminating the microorganisms present in the material, through a sterilization process. Different sterilization methodologies have been applied to decontaminate biomaterials, including the use of microwave radiation. The objective of this study was to evaluate the influence of the MW radiation application of a multi-phase biomaterial made of a three-phase mixture of calcium phosphates synthesized by wet chemical method. The results of this study showed that the application of MW radiation to ceramic samples containing the OCP phase causes the thermal decomposition of this phase, modifying its crystallinity index. This aspect should be taken into account when applying sterilization by applying MW radiation to ceramic samples with characteristics similar to those studied in this work.

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Section: Methodsmentioning

confidence: 99%

“…The objective of this study was to evaluate the influence of the MW radiation application of a multi-phase biomaterial made of a three-phase mixture of calcium phosphates synthesized by wet chemical method [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the influence of microwaves radiation on a biomaterial composed of three phases of calcium phosphates

2020

Biointerface Res Appl Chem

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“…Hydroxyapatite, amorphous calcium phosphates, calcium triphosphate and calcium octaphosphate are the main components present in bones and teeth. Calcium phosphates are easily synthesized, playing an important role in regenerative medicine, being able to be used as bone implants [1][2][3][4][5][6]. There are different ways of synthesizing phosphates, the most commonly used being wet chemical method.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic application and spray drying during amorphous calcium phosphate synthesis

2019

Lett Appl NanoBioSci

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Hydroxyapatite, amorphous calcium phosphates, calcium triphosphate and calcium octaphosphate are the main components present in bones and teeth. Calcium phosphates are easily synthesized, playing an important role in regenerative medicine, being able to be used as bone implants. There are different ways of synthesizing phosphates, the most commonly used being wet chemical method. The objective of this work was to study the influence of the use of ultrasound and spray drying on the synthesis of amorphous calcium phosphate. Two synthetic variants were studied. One without ultrasound application and the other with ultrasound application. The samples obtained were characterized by X-ray diffraction, FTIR spectroscopy and scanning electron microscopy. The particle size by electron microscopy and the calcium content by atomic absorption was determined. The results showed that when spray drying is applied, particle sizes of less than 261 nm are obtained in the samples synthesized without ultrasound application, being less than 59 nm in the samples synthesized with ultrasound application. The statistical analysis by ANOVA showed significant differences between the particle sizes of the samples synthesized without ultrasound application and the samples synthesized by applying ultrasound. In both cases the particles were spherical. The results obtained show that the application of ultrasound during the synthesis process decreases the particle size, increasing the surface area, which favors the spray drying process.

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“…They are present in the bone together with hydroxyapatite, which facilitates its use as a bioceramics [1][2][3][4][5][6]. Amorphous calcium phosphates (ACP), octacalcium phosphate (OCP) and tricalcium phosphate (TCP) are the main phosphates present in biological systems [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…These waves need a means to spread causing a phenomenon known as cavitation. This process allows the production of small particles in the form of nanoparticles [8,13,14]. The chemical physical characteristics of the calcium phosphate nanoparticles synthesized by wet chemistry method allow their use in the development of Scaffolds for bone regeneration [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Statistical evaluation of the effect of ultrasound on the synthesis of calcium phosphates

2019

Biointerface Res Appl Chem

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Calcium phosphates are widely used materials in tissue engineering due to their biocompativility and bioactivity. They are present in the bone along with the hydroxyapatite, which facilitates its use as a bioceramic. The mechanical and biological properties of the material obtained in the synthesis process are determined by the size of the particles. There are different ways to decrease the particle size of the materials. Among the methodologies used is the application of ultrasonic radiation. The objective of this work was to statistically evaluate the influence of the ultrasonic application during the synthesis of different phases of calcium phosphates, as well as the type of drying. The particle size determination was performed by scanning electron microscopy. The statistical comparison was made using one way ANOVA. Previously, the hypotheses necessary to validate the model were evaluated. The results were interpreted through its implementation in a statistical software InfoStat (2017 version). The results allow us to conclude that the application of ultrasound during the synthesis process significantly influences the particle size. The type of drying had no significant influence on the particle size.

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Synthesis by Wet Chemical Method of Different Phases of Apatites Applying Ultrasound

Cited by 5 publications

References 0 publications

Evaluation of the influence of microwaves radiation on a biomaterial composed of three phases of calcium phosphates

Evaluation of the influence of microwaves radiation on a biomaterial composed of three phases of calcium phosphates

Ultrasonic application and spray drying during amorphous calcium phosphate synthesis

Statistical evaluation of the effect of ultrasound on the synthesis of calcium phosphates

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