Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110α inhibitors

The synthesis and tuberculostatic activity of benzenesulfonohydrazide derivatives

“…The spectral analyses were in accordance with the assigned structures. In 1 H NMR spectra of compounds (7-11) and (13)(14)(15)(16)(17), the signal of one NH group proton was visible in the form of a multiplet common with aromatic protons in the range of 7.20 to 7.93 ppm as a rule. Only in the case of compounds (12,18), the signal of the NH group proton appeared in the form of a well-separated singlet at 7.18 (12) and 7.85 ppm (18).…”

“…N -(Pyrrolidine-1-carbonothioyl)benzenesulfonohydrazide (7 4-Methyl-N -(4-phenylpiperazine-1-carbonothioyl)benzenesulfonohydrazide (14). IR: 3268…”

“…Among others, they exhibit antimycotic [9,10], antiinflammatory [11], and antibacterial [12,13] activity. Antineoplastic action of that chemical group has also been reported [14].…”

Microwave-assisted synthesis of benzenesulfonohydrazide and benzenesulfonamide cyclic imide hybrid molecules and their evaluation for anticancer activity

“…Hence, there is a persistent need to develop better anticancer drugs by continuously synthesizing novel molecules and screening them for anticancer activity to obtain new leads. Sulfonohydrazide, sulfonamide and cyclic imide derivatives are examples of such novel molecules reported to exhibit anticancer activities (Arkinstall et al, 2001;Kendall et al, 2007;Cheng et al, 2014;Amin et al, 2013;Wang et al, 2014;Ghorab et al, 2014a, b;Jia et al, 2014;Machado et al, 2011Machado et al, , 2013Seliga et al, 2013;Li et al, 2009). Apart from anticancer activity, sulfonohydrazide, sulfonamide and cyclic imide derivatives are also reported to exhibit anti-inflammatory (Choi et al, 1995;Keche et al, 2012;Bock et al, 2006), antifungal (Dixit et al, 2010;Ezabadi et al, 2008;West and Cornell, 1998), antibacterial (Frlan et al, 2011;Dragostin et al, 2013;Prado et al, 2004), antimicrobial (Mahmoud et al, 2010;Kumar et al, 2014a;Al-Salahi et al, 2010), antioxidant (Sirajuddin et al, 2013;Mahdavi et al, 2014;Gul et al, 2013) and hypoglycemic (Bezuglyi et al, 1979;Faidallah and Khan, 2012;Abdel-Aziz et al, 2011) activities.…”

A Facile and Efficient One-Pot Regioselective Synthesis of 2-Hydroxyalkyl Dithiocarbamates under Catalyst-Free Conditions

“…Sulfur containing compounds are found in many products of biological [1][2][3][4] and medical [5][6][7] relevance as well as in commercial drugs [8].…”