Synthesis, biological evaluation and docking study of a new series of di-substituted benzoxazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents

Consecutive Oxidation/Condensation/Cyclization/Aromatization Sequences Catalyzed by Nanostructured Iron(III)‐Porphyrin Complex towards Benzoxazole Derivatives

“…Among diverse fused-ring heterocyclic compounds, the benzoxazole scaffold broadly exists in numerous compounds with many and various biological activities including antibacterial, anticancer, anti-measles virus and anti-HIV activities. [9,10] A survey of the literature reveals that the benzoxazole scaffold is an excellent template for anti-inflammatory activity, [10] with low side effects and considerable gastric safety margins. On the other hand, a range of cytotoxic natural products such as natural antimycobacterial pseudopteroxazole, [11,12] salvianen, [13] AJI9561, [14] and UK-1(bisbenzoxazole) [15] holds benzoxazole moiety (Figure 1).…”

“…Heterocycles are cyclic compounds composed of carbon, hydrogen, and heteroatom (including oxygen, or nitrogen, or both O and N) Benzoxazoles contain O and N heteroatoms and are a significant class of benzo‐fused heterocyclic products. Among diverse fused‐ring heterocyclic compounds, the benzoxazole scaffold broadly exists in numerous compounds with many and various biological activities including antibacterial, anticancer, anti‐measles virus and anti‐HIV activities , …”

Discovery of 6‐Arylurea‐2‐arylbenzoxazole and 6‐Arylurea‐2‐arylbenzimidazole Derivatives as Angiogenesis Inhibitors: Design, Synthesis and in vitro Biological Evaluation

“…[27][28][29][30][31][32] Many of their derivatives are used for their anticancer, [33][34][35][36][37] antiviral, [38][39][40][41][42] antifungal, [43][44][45][46] antimicrobial, [47][48][49][50] anti-inflammatory, [51][52][53][54] analgesic, [55][56][57] andi mmunotropic [58][59][60] activities. [27][28][29][30][31][32] Many of their derivatives are used for their anticancer, [33][34][35][36][37] antiviral, [38][39][40][41][42] antifungal, …”

“…Benzoxazoles and benzimidazoles are ah ighly significant group of biological molecules that are widely found in agrochemicals, pharmaceuticals, synthetic drugs, and bioactive natural products. [27][28][29][30][31][32] Many of their derivatives are used for their anticancer, [33][34][35][36][37] antiviral, [38][39][40][41][42] antifungal, [43][44][45][46] antimicrobial, [47][48][49][50] anti-inflammatory, [51][52][53][54] analgesic, [55][56][57] andi mmunotropic [58][59][60] activities. Recently,6-substituted benzoxazole or benzimidazole derivatives have been developed as multi-kinasei nhibitors, including tyrosine and serine/threonine kinases.…”

Eco-Friendly Syntheses of 2-Substituted Benzoxazoles and 2-Substituted Benzothiazoles from 2-Aminophenols, 2-Aminothiophenols and DMF Derivatives in the Presence of Imidazolium Chloride

“…The 2-substituted benzoxazoles and 2-substituted benzothiazoles are well-known substructures in a variety of biologically active natural compounds [1,2], photoluminescent materials [3,4] or pharmaceutical agents such as riluzole, a treatment for amyotrophic lateral sclerosis [5], zopolrestat, an aldose reductase inhibitor used for the treatment of diabetes mellitus [6], the antitumor agent phortress, which acts via binding to aryl hydrocarbon receptors [7], 2-phenylbenzo[d]oxazole-7-carboxamide derivatives which are potential Staphylococcus aureus sortase A Inhibitors [8], and so on [9,10] (Figure 1).…”