Synthesis, biological evaluation, and docking studies of novel thiourea derivatives of bisindolylmethane as carbonic anhydrase II inhibitor

Friedel‐Crafts dealkylation reaction mediated by a stereoselective proton transfer in the fragmentation of protonated cyclic indolyl α‐amino esters

“…Indole is one of the most important natural chemical templates occurring in various biologically active molecules and it has been proved to be antiviral, antioxidant, antiproliferative, etc. [1][2][3][4][5][6] As a unique but unnatural scaffold for peptides and peptidomimetics, optically active cyclic α-amino acids with indole functionalization have attracted considerable attention. [7][8][9][10][11][12][13] Recently, Jia and co-workers [14] have successfully synthesized a series of indole-functionalized chiral cyclic α-amino esters by a catalytic asymmetric Friedel-Crafts alkylation reaction, providing an efficient approach to chiral α-tetrasubstituted indolic α-amino acids.…”

Synthesis, In vitro and Docking Studies of New Flavone Ethers as α‐Glucosidase Inhibitors

“…In continuation of our study on enzyme inhibition activity (48,(55)(56)(57)(58), compounds 1-15 had been and evaluated for their a-glucosidase inhibition activity. The assay had been carried out using baker's yeast a-glucosidase (EC 3.2.1.20).…”

Synthesis, in vitro evaluation and molecular docking studies of biscoumarin thiourea as a new inhibitor of α-glucosidases

“…Thiourea and urea have attracted much attention as drug candidates against a variety of diseases due to their bioactivities and broad spectrum as pesticides and in pharmacological activities [15]. A variety of thiourea derivatives and their metal complexes exhibit analgesic, anti-inflammatory [16], carbonic anhydrase inhibitors [17], b-glucuronidase [18], antiurease [19] and antimicrobial activities [20,21]. Thiourea derivatives also possess anti-HCV [22], anti-HIV, antituberculosis, and antileukemic activity [23].…”