Synthesis, biological activity screening and molecular modeling study of acylaminoacetamide derivatives

Abstract

In this study, non-rigid analogs of thalidomide have been designed in order to develop potentially active, more effective and safer lead molecules for disorders caused or contributed by inflammation. Five different series of acylaminoacetamide compounds were synthesized, and the biological inhibitory potency of the title compounds has been determined by evaluating their effects on COX-2 isoenzyme expression and PGE 2 production in A549 (human lung adenocarcinoma) cell lines. Among the studied series, N-[2-(isopropylamino)-2-oxoethyl]isonicotinamide is the most active inhibitory compound on COX-2 isoenzyme expression, and N-[2-oxo-2-(pyrolydine-1-yl)etyl]isonicotinamide is the most active inhibitory compound on the biosynthesis of PGE 2 . Molecular docking studies and molecular dynamics simulations were also applied to investigate non-covalent interactions of the most active compounds inside the active side of the crystal structure of murine cyclooxygenase 2 (mCOX-2) isoenzyme.

4‐Sulfamoylphenylalkylamides as Inhibitors of Carbonic Anhydrases Expressed in Vibrio cholerae

“…The experimental properties for 17–19, 25–30 and 33–35 matched with those reported in literature. [ 26 , 27 , 28 , 29 , 30 , 31 , 32 ]…”

Synthesis of Dipeptides and Ruthenium-Phenanthroline Derivative for Photo Redox Studies

“…Synthesis Part: The dinitro-fluorobenzene were treated with glycine under base condition to get product 13 4, which is treated with oxalyl chloride to get acid chloride product 14 5. The free glycine ester 15 6 is prepared with base treatment in 90 yield. On combining the 5 with 6 to gives the dipeptide 16 ester 7 in 60 % yield.…”