Synthesis, biological activity and toxicity to zebrafish of benzamides substituted with pyrazole-linked 1,2,4-oxadiazole

Abstract

A series of novel benzamides substituted with pyrazole-linked 1,2,4-oxadiazole was designed and synthesized by using the splicing principle of active substructures.

Synthesis, Biological Activity, and Toxicity to Zebrafish Embryo of Benzamides Substituted with 1,2,4-Oxadiazole-Linked Pyrazole

“…The round bacteria cake was punched with a puncher and picked up to the center of the culture dish with an inoculation needle, and then the culture dish was placed in an incubator at 27 °C. The colony diameter was measured after 48–72 h (bixafen as control agent). − …”

Thiol-promoted intermolecular cyclization to synthesize 1,2,4-oxadiazoles including tioxazafen under transition metal-free conditions

“…1 Among various heterocyclic compounds, substituted 1,2,4-oxadiazoles have been widely researched due to their worthy applications ranging from pharmacophore 2 to functional materials. 3 Furthermore, the widespread use of 1,2,4-oxadiazole as a scaffold in medicinal chemistry establishes this skeleton as a component of the privileged structure, and its derivatives show a wide range of biological activities, 4 such as anticancer, 5 anti-inflammatory, 6 anti-diabetic, 7 anti-parasitic, 8 and antibacterial 9 (Fig. 1).…”