Synthesis, biological activity and assembly of pH-responsive alkyl-substituted naphthalene-type hydrazonotriazole organogelators

Ashour, Gadeer R. S.; Alqahtani, Alaa M.; Abualnaja, Matokah; Katouah, Hanadi A.; Alenazi, Noof A.; Aljohani, Meshari M.; Shaaban, Fathy; El‐Metwaly, Nashwa M.

doi:10.1016/j.arabjc.2023.105063

Cited by 1 publication

(1 citation statement)

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“…In this context, Ashour et al reported hydrazone derivatives 56 a-e (Figure 11), and their anticancer and antibacterial activities were analyzed. [105] The viability of hydrazonotriazole 56 c was reduced; the percentage of viable cells was 92.35 %. It was discovered that the hydrazonotriazole analogs 56 a and 55 b with the shortest alkoxy units have respective viabilities of 88.07 % and 84.37 %.…”

Section: Anticancer Agentsmentioning

confidence: 95%

Naphthyl‐Based Chalcone Derivatives: A Multifaceted Player in Medicinal Chemistry

Mahesha,

Shetty

2024

ChemistrySelect

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Research has placed a great deal of emphasis on molecule development and discovery with substantial biological profiling in recent years. Despite the significant side effects, medicinal chemists have long strived to synthesize drug molecules with the highest level of therapeutic activity and the lowest possible level of toxicity. The naphthyl‐based chalcone derivatives have drawn attention due to their simple structures and wide range of pharmacological effects. The main focus of this review is to outline the biologically active molecules based on naphthyl moiety‐substituted chalcone derivatives developed over the years. A synopsis of pharmacological screening, including relevant structure‐activity relationships, action mechanisms, and possible therapeutic applications, is provided in this article. It is true that prospective hybrids combining the naphthyl moiety with different chalcone pharmacophores are needed to address drug resistance and improve specificity. Therefore, this review may be useful in the development and design of new, highly successful therapeutic drugs based on previously reported methodologies.

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Section: Anticancer Agentsmentioning

confidence: 95%