Synthesis, biodistribution and excretion of radiolabeled poly(2-alkyl-2-oxazoline)s

Gaertner, Florian; Luxenhofer, Robert; Blechert, Birgit; Jordan, Rainer; Essler, Markus

doi:10.1016/j.jconrel.2007.02.015

Cited by 227 publications

(184 citation statements)

References 47 publications

Supporting

Mentioning

175

Contrasting

Unclassified

Order By: Relevance

“…These types of polymers can be applied in temperature sensors, [18] protein chromatography [19] and various biomedical applications such as drug delivery and tissue engineering [1,20]. For these latter applications thermoresponsive polymers are needed that are biocompatible and that can be conveniently functionalized.…”

Section: Introductionmentioning

confidence: 99%

Thermal Properties of Methyl Ester-Containing Poly(2-oxazoline)s

et al. 2015

View full text Add to dashboard Cite

This paper describes the synthesis and thermal properties in solution and bulk of poly(2-alkyl-oxazoline)s (PAOx) containing a methyl ester side chain.Homopolymers of 2-methoxycarbonylethyl-2-oxazoline (MestOx) and 2-methoxycarbonylpropyl-2-oxazoline (C3MestOx), as well as copolymers with 2-ethyl-2-oxazoline (EtOx) and 2-n-propyl-2-oxazoline (nPropOx), with systematic variations in composition were prepared. The investigation of the solution properties of these polymers revealed that the cloud point temperatures (T CP s) could be tuned in between 24˝C and 108˝C by variation of the PAOx composition. To the best of our knowledge, the T CP s of PMestOx and PC3MestOx are reported for the first time and they closely resemble the T CP s of PEtOx and PnPropOx, respectively, indicating similar hydrophilicity of the methyl ester and alkyl side chains. Furthermore, the thermal transitions and thermal stability of these polymers were investigated by DSC and TGA measurements, respectively, revealing amorphous polymers with glass transition temperatures between´1˝C and 54˝C that are thermally stable up to >300˝C.

show abstract

Section: Introductionmentioning

confidence: 99%

Thermal Properties of Methyl Ester-Containing Poly(2-oxazoline)s

et al. 2015

View full text Add to dashboard Cite

show abstract

“…All detected peaks presented a peak-to-peak average distance equal to 85 g/mol, which confi rmed the repeating In addition to the main peaks, second minor peaks with lower masses relative to the main peaks at 38-mass differences were detected. For MALDI-ToF spectra of poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline), this phenomenon has been observed earlier and could be attributed to an initiation of a small fraction of monomers with a proton (H + ) instead of the initiator (Gaertner et al, 2007, Jordan et al, 2001). Thus, a minor part of the polymer presents as (H)-PMOXA-(COOC 2 H 5 ) instead of (C 3 H 3 )-PMOXA-(COOC 2 H 5 ).…”

Section: Resultsmentioning

confidence: 67%

The synthesis of polymeric dual-functional antimicrobial surface based on poly(2-methyl-2-oxazoline)

Pidhatika¹,

Rakhmatullina

2015

IJBiotech

View full text Add to dashboard Cite

There is a high interest in the development of antimicrobial coatings to fi ght bacterial infections. We present the development of dual-functional antimicrobial surface, in which a biopassive platform was functionalized with bioactive compounds on the surface, using a graft copolymer system poly(L-lysine)-graftpoly(2-methyl-2-oxazoline)-quarternery ammonium compound (PLL-g-PMOXA-QAC). Alkyne functionality was introduced to the PMOXA chain at α-terminus by initiating the living cationic polymerization of 2-methyl-2-oxazoline with a propargylic-initiator. The reaction was terminated with carboxy derivative-terminator that allows grafting of the polymeric chain from the β-terminus to poly(L-lysine) (PLL) backbone, resulting in graft copolymer alkynyl PLL-g-PMOXA. The conjugation between alkynyl PLL-g-PMOXA and QAC was then performed using click reaction. The chemical structures of the polymers were characterized by MALDI-TOF spectrometry and NMR spectroscopy. The results demonstrate that we have successfully synthesized PLL-g-PMOXA-QAC copolymer with grafting density (number of lysine/number of PMOXA) of 0.33. The resulting PLL-g-PMOXA-QAC copolymer was then immobilized onto carboxylated tissue cultured polystyrene (TCPS) surface and exposed to bacteria solution to test its dual-functional properties. Preliminary live-and-dead bacteria study indicates dual-functionality of the PLL-g-PMOXA-QAC-coated surface.

show abstract

“…Authors used 111 In-labeled polymers to study the distribution and excretion of such polymers in mice [79]. Similarly, 125 I-labeled 2-oxazoline-based copolymers were examined after their intravenous administration to mice, and their biodistribution was assessed [80].…”

Section: In Vitro and In Vivo Visualization Methodsmentioning

confidence: 99%