Synthesis, biocompatible, and self-assembly properties of poly (ethylene glycol)/lactobionic acid-grafted chitosan

Song, Xiaoli; Wang, Juan; Luo, Xiadan; Xu, Chunlan; Zhu, Ai‐Min; Guo, Rong; Yan, Caifeng; Zhu, Peizhi

doi:10.1080/09205063.2014.918465

Cited by 9 publications

(2 citation statements)

References 33 publications

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“…The degree of hemolysis is within an acceptable range. [37] Alginic aldehyde and gelatin Inverse miniemulsion technique – Drug- and gene-delivery Haemolysis Plasma clotting All the evaluated parameters are within the acceptable range. [38] Lipids modified with the polymer gelatin Double emulsion solvent evaporation method p.o.…”

Section: Hemocompatibility Characteristics or Improvement Strategies Of Various Nanocarriersmentioning

confidence: 92%

Relationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility: What can we learn from the literature

Guo

Shi

et al. 2021

Asian Journal of Pharmaceutical Sciences

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This article discusses the various blood interactions that may occur with various types of nano drug-loading systems. Nanoparticles enter the blood circulation as foreign objects. On the one hand, they may cause a series of inflammatory reactions and immune reactions, resulting in the rapid elimination of immune cells and the reticuloendothelial system, affecting their durability in the blood circulation. On the other hand, the premise of the drug-carrying system to play a therapeutic role depends on whether they cause coagulation and platelet activation, the absence of hemolysis and the elimination of immune cells. For different forms of nano drug-carrying systems, we can find the characteristics, elements and coping strategies of adverse blood reactions that we can find in previous researches. These adverse reactions may include destruction of blood cells, abnormal coagulation system, abnormal effects of plasma proteins, abnormal blood cell behavior, adverse immune and inflammatory reactions, and excessive vascular stimulation. In order to provide help for future research and formulation work on the blood compatibility of nano drug carriers.

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Section: Hemocompatibility Characteristics or Improvement Strategies Of Various Nanocarriersmentioning

confidence: 92%

Relationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility: What can we learn from the literature

Guo

Shi

et al. 2021

Asian Journal of Pharmaceutical Sciences

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“…[233] Moreover, chitosan hemolysis was found to be reduced by conjugation with methoxy poly (ethylene glycol) (mPEG). [234] Song et al [235] assessed the ability of La-modified mPEG oligochitosan conjugate micelles, encapsulating AmpB, to increase the fungal cellular uptake. Candida albicans was employed to assess the cellular uptake of FITC-labeled conjugates, using FITC@mPEG NPs and FITC@mPEGCh NPs as controls.…”

Section: Fungal Uptake Studiesmentioning

confidence: 99%

Biomedical and Pharmacological Uses of Fluorescein Isothiocyanate Chitosan‐Based Nanocarriers

Caprifico

Polycarpou

Foot

et al. 2020

Macromolecular Bioscience

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with a DDA ranging between 70% and 85% becomes soluble in dilute acidic solutions such as acetic acid or formic acid. [1] Indeed, the primary amino groups of chitosan have a pK a of ≈6.5 so that, following protonation, they confer upon chitosan the feature of solubility in weakly acidic aqueous solution, allowing the polymer to be easily manipulated. [3] The DDA of chitosan plays a key role in determining its physicochemical properties, which are affected by the proportion of free amino groups (-NH 2) remaining on the polymeric chain upon deacetylation. Both the primary amino and secondary hydroxyl groups behave as reactive functional groups on chitosan. Indeed, these groups allow chitosan to be susceptible to chemical modifications such as acylation, tosylation, quaternization, alkylation, and O-carboxymethylation. [4] As a result, the chitosan structure can be functionalized and optimized to improve drug loading or release. [5] Chitosan-based nanocarriers (ChNCs), including nanoparticles (NPs), micelles, or polyplexes, have received significant attention for their numerous advantageous features such as natural sourcing, biodegradability, easy functionalizations, and low toxicity. [6] The mucoadhesive property of chitosan is key for drug delivery purposes. [7] Indeed, chitosan is a positively charged polymer that can form electrostatic bonds with the negatively charged mucous layer, made of mucin glycoproteins that cover the epithelial cells of the mucosa. The establishment of these bonds allows drug-loaded ChNCs to exhibit higher absorption and retention times at the target, while reducing dosing frequency. [8] Furthermore, chitosan is used as permeation enhancer since increases the uptake of the drugs through a transient and reversible opening of the tight junctions (TJs) protecting the paracellular pathway between endothelial cells in the so-called blood-brain barrier (BBB). [9] This is due to F-actin depolymerization and leakage of the TJ protein zonula occludens-1. [7] The small size and large surface area of NCs allow their passage through biological membranes, such the BBB, and accumulation at the intracellular (such as lysosomes) or intranuclear (DNA or RNA) target site. [10] ChNCs are distinctive for their ability to protect the encapsulated therapeutic agent and improve its bioavailability by altering the pharmacokinetics. [10] The endocytic mechanisms responsible for the internalization of ChNCs as a drug delivery system may differ according to the cell type and the drug to be delivered. Numerous biological and pharmacological properties characterize chitosan. These include antitumor, antifungal, antioxidant, immunoenhancing, and wound healing properties. [11] Furthermore, chitosan is Chitosan-based nanocarriers (ChNCs) are considered suitable drug carriers due to their ability to encapsulate a variety of drugs and cross biological barriers to deliver the cargo to their target site. Fluorescein isothiocyanatelabeled chitosan-based NCs (FITC@ChNCs) are used extensively in biomedical and pharmacological...

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Linolenic acid-modified methoxy poly (ethylene glycol)-oligochitosan conjugate micelles for encapsulation of amphotericin B

Song

Wen

Deng

et al. 2019

Carbohydrate Polymers

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Synthesis, biocompatible, and self-assembly properties of poly (ethylene glycol)/lactobionic acid-grafted chitosan

Cited by 9 publications

References 33 publications

Relationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility: What can we learn from the literature

Relationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility: What can we learn from the literature

Biomedical and Pharmacological Uses of Fluorescein Isothiocyanate Chitosan‐Based Nanocarriers

Linolenic acid-modified methoxy poly (ethylene glycol)-oligochitosan conjugate micelles for encapsulation of amphotericin B

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