Synthesis, Bioassays and Field Evaluation of Hydroxycoumarins and their Alkyl Derivatives as Repellents or Kairomones for Aedes albopictus Skuse (Diptera: Culicidae)

Andrianjafy, Tovo Mbolatiana; Ravaomanarivo, Lala Harivelo Raveloson; Ramanandraibe, Voahangy; Rakotondramanga, Maonja Finaritra; Mavingui, Patrick; Lemaire, Marc

doi:10.1007/s10886-018-0931-7

Cited by 9 publications

(13 citation statements)

References 31 publications

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“…A synergistic effect was observed for the blend 4-hydroxycoumarin (10 mg) and octenol (2 mg) in this experiment. We reported similar results with Aedes using the sentinel-type trap 20 . It seems that it is 4-hydroxycoumarin that plays a major role in synergy because even without octenol the selectivity remains high compared to other products.…”

Section: Discussionsupporting

confidence: 79%

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Field assessment of 4-hydroxycoumarin as an attractant for anthropophilic Anopheles spp. vectors of malaria in Madagascar

Andrianjafy

Ramanandraibe

Andrianarijaona

et al. 2020

Sci Rep

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Mosquito-borne diseases like malaria are a major public health problem in tropical countries, such as Madagascar. Female Anopheles mosquito vectors the human malaria parasites (Plasmodium spp.) and is important indicator in malaria surveillance activities. Among the various means of vector control in Madagascar, the use of attractants for mass trapping of target species could be an alternative to insecticides. The aim of this study is to evaluate whether 4-hydroxycoumarin can be used as an attractant for anthropophilic Anopheles spp. vectors of malaria. For this, a field study was conducted using CDC light traps in the village of Ambohidray, Madagascar. 16 days of trapping was conducted and four replicates nights were performed for each product tested. 4-hydroxycoumarin, octenol and two types of blend of these products were tested. The results showed that 4-hydroxycoumarin (2 mg) have a significant attractive effect on Anopheles spp. and significant selectivity towards Anopheles gambiae s.l, and Anopheles mascarensis which are both significant malaria vectors in Madagascar. A synergy of 4-hydroxycoumarin with octenol was found to attract these mosquito vectors. A significant decrease in vector populations was observed during this experiment. These results suggest that 4-hydroxycoumarin could be useful for malaria surveillance and the control of vector populations. Mosquito-borne diseases present a major public health threat in tropical and subtropical areas and disproportionately impact developing nations, such as Madagascar 1. Among numerous mosquito vectors existent in Madagascar several Anopheles species are responsible for the transmission of malaria parasites 2-4. Due to their distribution, malaria is endemic to 90% of the country 5 and is the fourth leading cause of death in Madagascar 6. In order to limit the transmission of malaria, several methods of control have been implemented such as the use of long lasting insecticide-treated mosquito nets (LLINs) 7 , and indoor residual spraying (IRS) 8 to protect populations in regions with a high potential for epidemics 9. These control methods have shown significant efficacy, but they are also insufficient in the long term due to the rapid amplification of insecticide resistance in vector populations 10,11. In addition, controlling mosquito populations through the use of larvicides and adulticides has found to have negative impacts on ecosystems 12-14. For these reasons, the explorations of other more sustainable and environmentally friendly alternatives are encouraged worldwide 15,16. The use of attractants for selective and mass trapping has been suggested as a promising complementary to insecticide for malaria vector surveillance, control and reduction 17-19. A recent study has shown that 4-hydroxycoumarin, a compound derived from coumarin, a natural substance of plant origin, has a significant attractiveness activity on the mosquito Aedes albopictus, a mosquito vector of Dengue and Chikungunya, in

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Section: Discussionsupporting

confidence: 79%

“…laboratory and field assays 20 . Preliminary field tests in the east of Madagascar, using CDC light traps, have shown that the same compound also attracts Anopheles mosquito species.…”

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confidence: 99%

Field assessment of 4-hydroxycoumarin as an attractant for anthropophilic Anopheles spp. vectors of malaria in Madagascar

Andrianjafy

Ramanandraibe

Andrianarijaona

et al. 2020

Sci Rep

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“…Fay [56], the Fay-Prince trap [57], the black cylinder suction trap [58], duplex cone trap [59]) and lure-based traps. For the latter, artificial odours and attractants have been developed and tested for use in traps such as kairomone blends [60][61][62][63][64][65][66][67], BG-Lure® cartridges [68][69][70], and carbon dioxide (CO2) 6 [71]. Additionally other trapping methods have been developed that use live hosts as lures (e.g.…”

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confidence: 99%

The Mosquito Electrocuting Trap As An Exposure-Free Method For Measuring Human Biting Rates ByAedesMosquito Vectors

Ortega-López

Pondeville

Kohl

et al. 2019

Preprint

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BackgroundEntomological monitoring of Aedes vectors has largely relied on surveillance of larvae, pupae and non-host-seeking adults, which have been poorly correlated with human disease incidence. Exposure to mosquito-borne diseases can be more directly estimated using Human Landing Catches (HLC), although this method is not recommended for Aedes-borne arboviruses.We evaluated a new method previously tested with malaria vectors, the Mosquito Electrocuting Trap (MET) as an exposure-free alternative for measuring landing rates of Aedes mosquitoes on people. Aims were to 1) compare the MET to the BG-sentinel (BGS) trap gold standard approach for sampling host-seeking Aedes vectors; 2) characterize the diel activity of Aedes vectors and their association with microclimatic conditions. MethodsThe study was conducted over 12 days in Quinindé -Ecuador in May 2017. Mosquito sampling stations were set up in the peridomestic area of four houses. On each day of sampling, each house was allocated either a MET or a BGS trap, which were rotated amongst the four houses daily in a Latin square design. Mosquito abundance and microclimatic conditions were recorded hourly at each sampling station between 07:00-19:00 hours to assess variation between vector abundance, trapping methods, and environmental conditions. All Aedes aegypti females were tested for the presence of Zika (ZIKV), dengue (DENV) and chikungunya (CHIKV) viruses.3 ResultsA higher number of Ae. aegypti females were found in MET than in BGS collections, although no statistically significant differences in mean Ae. aegypti abundance between trapping methods were found. Both trapping methods indicated female Ae. aegypti had bimodal patterns of host seeking, being highest during early morning and late afternoon hours. Mean Ae. aegypti daily abundance was negatively associated with daily temperature. No infection by ZIKV, DENV or CHIKV was detected in any Aedes mosquitoes caught by either trapping method. ConclusionWe conclude the MET performs at least as well as the BGS standard, and offers the additional advantage of direct measurement of per capita human biting rates. If detection of arboviruses can be confirmed in MET-collected Aedes in future studies, this surveillance method could provide a valuable tool for surveillance and prediction on human arboviral exposure risk. BACKGROUNDMosquito--borne viruses (arboviruses) are an important cause of diseases in humans and animals. In 2017, estimates suggested that mosquitoes were responsible for approximately 137 millions human arboviral infections with dengue (DENV), chikungunya (CHIKV), and Zika virus (ZIKV) being the most important [1]. Arbovirus transmission to humans depends on multiple factors that involve spatial movement and immunity of human populations [2-7], socioeconomic factors and access to basic services (especially water) [8][9][10][11], and the ecology and distribution of the mosquito vectors that transmit them [12][13][14][15][16][17][18][19]. These factors combine to determine the distribution and intens...

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“…This test allows to determine the overall deviation from the expected proportion (50:50 in our case) and whether there is significant variation among the repeated trials (McDonald, 2014). For each assay, the KI was also calculated to assess the relative attractiveness of the different bacterial strains (Andrianjafy et al, 2018). This index represents the percentage of the difference between the number of mosquitoes in the compartment containing the tested isolate (P) and in the control (sterile LBm medium) (T) divided by the sum of mosquitoes in both compartments (P + T).…”

Section: Growth Curvesmentioning

confidence: 99%

Identification of human skin bacteria attractive to the Asian Tiger mosquito

Michalet

Minard

Chevalier

et al. 2019

Environmental Microbiology

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Summary Aedes albopictus is a vector of arboviruses and filarial nematodes. Originating from Asia, this mosquito has rapidly expanded its geographical distribution and colonized areas across both temperate and tropical regions. Due to the increase in insecticide resistance, the use of environmentally friendly vector control methods is encouraged worldwide. Using methods based on semiochemicals in baited traps are promising for management of mosquito populations. Interestingly, human skin microbiota was shown to generate volatile compounds that attract the mosquito species Anopheles gambiae and Aedes aegypti. Here, we investigated the composition of skin bacteria from different volunteers and the attractive potential of individual isolates to nulliparous Ae. albopictus females. We showed that three out of 16 tested isolates were more attractive and two were more repulsive. We identified dodecenol as being preferentially produced by attractive isolates and 2‐methyl‐1‐butanol (and to a lesser extent 3‐methyl‐1‐butanol) as being overproduced by these isolates compared with the other ones. Those bacterial volatile organic compounds represent promising candidates but further studies are needed to evaluate their potential application for baited traps improvement.

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Synthesis, Bioassays and Field Evaluation of Hydroxycoumarins and their Alkyl Derivatives as Repellents or Kairomones for Aedes albopictus Skuse (Diptera: Culicidae)

Cited by 9 publications

References 31 publications

Field assessment of 4-hydroxycoumarin as an attractant for anthropophilic Anopheles spp. vectors of malaria in Madagascar

Field assessment of 4-hydroxycoumarin as an attractant for anthropophilic Anopheles spp. vectors of malaria in Madagascar

The Mosquito Electrocuting Trap As An Exposure-Free Method For Measuring Human Biting Rates ByAedesMosquito Vectors

Identification of human skin bacteria attractive to the Asian Tiger mosquito

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