Synthesis, Antiviral, and Antimicrobial Activity of 1,2,4-Triazole Thioglycoside Derivatives

El‐Sayed, Hassan A.; Moustafa, A. H.; Haikal, Abd El‐Fattah Z.

doi:10.1080/10426507.2012.668990

Cited by 17 publications

(16 citation statements)

References 40 publications

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“…Some 1,2,4‐triazole compounds had been developed as commercial pesticide molecules, such as difenoconazole, prothioconazole, exoxiconazole, and amicarbazone (Figure ). Recently, differently substituted 1,2,4‐triazoles have been reported for their wide biological activities, such as antibacterial, antifungal, antiviral, insecticidal, and herbicidal activity.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and antifungal activity of novel 1,2,4‐triazole derivatives containing an amide moiety

Jiang

Fei

et al. 2019

Journal of Heterocyclic Chem

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A series of novel 1,2,4‐triazol derivatives containing an amide moiety were synthesized and their antifungal activities were evaluated. The results indicated that some of the target compounds possessed good antifungal activities. Among them, compounds 6a, 6g, 6k, and 6m showed excellent antifungal activities against Botrytis cinerea, with an inhibition rate of 91.8%, 90.1%, 93.6%, and 91.2% at a concentration of 50 μg/mL, which were superior to that of Pyrimethanil (82.8%). Meanwhile, compound 6b showed better antifungal activity against Phompsis sp, with an inhibition rate of 92.4%, in comparison with that of Pyrimethanil (85.1%).

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Section: Introductionmentioning

confidence: 99%

“…for their wide biological activities, such as antibacterial, [1,2] antifungal, [3][4][5] antiviral, [6] insecticidal, [7] and herbicidal [8,9] activity.…”

mentioning

confidence: 99%

Synthesis and antifungal activity of novel 1,2,4‐triazole derivatives containing an amide moiety

Jiang

Fei

et al. 2019

Journal of Heterocyclic Chem

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“…antimicrobial, anticancer, anticonvulsant, anti-inflammatory, antioxidant) 1 and can undergo various types of reactions. 2 These reaction could involve the amino group, 3 the mercapto group, [4][5][6] or the endocyclic NH in the thione tautomer. 4,7 In addition, the proximity of the aforementioned reactive sites in 4-amino-1,2,4-triazole-3-thiones is inducive of ring closure reactions in which both amino and mercapto groups are involved.…”

Section: Introductionmentioning

confidence: 99%

Schiff Bases and Triazolothiadiazines Derived from A Thiophene-Substituted 4-Amino-3-Mercapto-1,2,4-Triazole

Roman¹

2019

Acta Chemica Iasi

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4-Amino-5-(thiophen-2-ylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione was synthesized and converted into the corresponding Schiff bases using several aromatic aldehydes. Reaction of this aminotriazolethione with phenacyl bromides lead to triazolothiadiazines, which were subsequently reduced with NaBH4 to dihydrotriazolothiadiazines. The latter type of fused heterocycle has been also obtained directly by reacting one of the previously obtained Schiff base with phenacyl bromides. NMR analysis confirmed the structures of the synthesized compounds.

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“…Using this technique, a large number of new drugs have been synthesized . 1,2,4‐Triazoles are pharmaceutically important compounds due to their antimicrobial , antifungal , anticancer , antioxidant , antihypertensive, and antiviral activities . Compounds with 1,2,4‐triazole moiety have been demonstrated to have anticonvulsant activity .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Some Novel 1,2,4‐Triazol‐3‐one Derivatives Bearing the Salicyl Moiety and Their Anticonvulsant Activities

Kahveci

Menteşe

Akkaya

et al. 2014

Archiv der Pharmazie

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A series of new 1,2,4-triazole-3-one derivatives bearing the salicyl moiety were synthesized by using microwave irradiation, and their chemical structures were identified by IR, (1) H NMR, (13) C NMR, elemental analysis, and LC-MS. The anticonvulsant activities of the compounds 4a-c, 4e, and 5a-e were evaluated by the Anticonvulsant Screening Program of the National Institute of Health, USA. The compounds had moderate anticonvulsant activities in the maximum electroshock-induced seizure and minimal clonic seizure models in mice, without any neurotoxic effects.

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Synthesis, Antiviral, and Antimicrobial Activity of 1,2,4-Triazole Thioglycoside Derivatives

Cited by 17 publications

References 40 publications

Synthesis and antifungal activity of novel 1,2,4‐triazole derivatives containing an amide moiety

Synthesis and antifungal activity of novel 1,2,4‐triazole derivatives containing an amide moiety

Schiff Bases and Triazolothiadiazines Derived from A Thiophene-Substituted 4-Amino-3-Mercapto-1,2,4-Triazole

Synthesis of Some Novel 1,2,4‐Triazol‐3‐one Derivatives Bearing the Salicyl Moiety and Their Anticonvulsant Activities

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