Synthesis, Antiproliferative and Antioxidant Activity of 3-Mercapto-1,2,4-Triazole Derivatives as Combretastatin A-4 Analogues

Synthesis, characterization and anticancer activity of Ni(II), Cu(II), Pd(II) and Au(III) complexes derived from novel Mannich base

“…Heterocyclic ring systems are found in a variety of substances, including alkaloids, antibiotics, vital amino acids, vitamins, hemoglobin, hormones, and a number of synthetic medications and colors 2 . Triazole as a heterocyclic compound provides a broad variety of medicinal activities and have a broad range of applications 4–7 and the fact that a large number of drugs contain triazole as a primary heterocyclic structural component to their pharmacological importance, 8 including anticonvulsants, antimalarial, antimicrobial, antitumor, antiviral, antiproliferative, anticancer, antioxidants, analgesics, antifungal, antiplasmodial, antibacterial, immunostimulants, and antidiabetic 9 . Imine compounds have been known since 1864 when Hugo Schiff was the first researcher who synthesized carbon nitrogen double bond (C═N) 10 .…”