Synthesis, antioxidant, and antiviral properties of pyrimidinylsulfamoyl azolyl acetamides

Divya, Kuppi Reddy Gari; Sowmya, Donthamsetty V.; Durgamma, Suram; Tharanath, Vadlamudi; Gopal, Divi Venkataramana Sai; Kumar, Malaka Venkateshwarulu Jyothi; Rao, Chippada Appa; Padmaja, A.; Padmavathi, V.

doi:10.1007/s00044-017-1956-0

Cited by 5 publications

(2 citation statements)

References 44 publications

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“…However these methodologies often suffer from longer reaction times, tedious procedures and in some cases lower yields. In fact, we have adopted dicyclohexylcarbodiimide (DCC) / 4‐dimethyl‐aminopyridine (DMAP), O ‐(7‐azabenzotriazol‐1‐yl)‐ N,N,N′,N′ ‐tetramethyluronium hexa‐fluorophosphate (HATU) / diisopropylethylamine (DIPEA), 1‐ethyl‐3‐(3‐dimethyl‐aminopropyl)carbodiimide (EDCI) / DIPEA, potassium ter.butoxide, O ‐(benzotriazol‐1‐yl)‐ N,N,N′,N′ ‐tetramethyluronium tetrafluoroborate (TBTU) / DIPEA and EDCI / DMAP for the development of amide linkage. Better yields were recorded in the presence of potassium ter.butoxide .…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Antimicrobial and Antioxidant Activities of Pyrimidinyl Benzothiazine Carboxamides

et al. 2019

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A variety of pyrimidinyl benzothiazine carboxamides were prepared from benzothiazine carboxylate and 4,6‐diaryl/heteroarylpyrimidinyl‐2‐amines. The compounds having 4‐nitro phenyl, 4‐pyridinyl and pyrazolyl ‐ pyrimidinyl benzothiazine carboxamide moieties 6 e, 6 i, 6 j, 6 k and 6 m displayed prominent antibacterial activity against Bacillus subtilis. Further, compounds having pyrrolyl, pyrazolyl, pyridinyl and indolyl units 6 f, 6 k, 6 m and 6 n displayed prominent antifungal activity against Aspergillus niger. On the other hand, compounds with electron donating substituents on the aromatic ring (6 b, 6 c) and those with furan moiety (6 g, 6 h and 6 l) displayed very good free radical scavenging activity greater than Ascorbic acid.

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Section: Resultsmentioning

confidence: 99%

Synthesis, Antimicrobial and Antioxidant Activities of Pyrimidinyl Benzothiazine Carboxamides

et al. 2019

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“…Functionalization of acid and their derivatives with amines is one of the most widely used methods for amide synthesis either by direct reaction of an amine with an acid or by reaction of acid derivatives with an amine in the presence of zinc acetate , brine , copper oxide , N , N , N ′ , N ′ ‐tetramethylethylenediamine , aluminium , triethylamine , etc. In fact, we have adopted dicyclohexylcarbodiimide/4‐dimethylaminopyridine , O ‐(7‐azabenzotriazol‐1‐yl)‐ N , N , N ′ , N ′ ‐tetramethyluronium hexaflourophosphate/diisopropylethylamine (DIPEA) , 1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide /DIPEA , O ‐(benzotriazol‐1‐yl)‐ N , N , N ′ , N ′ ‐tetramethyluronium tetrafluoroborate/DIPEA, and 1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide/dimethylaminopyridine for the development of amide group. In continuation of our efforts to synthesize, a variety of molecules benzazolyl azolyl sulfamoyl acetamides as effective antibacterial agents have been taken up.…”

Section: Introductionmentioning

confidence: 99%