Synthesis, antimicrobial, antimycobacterial and structure–activity relationship of substituted pyrazolo-, isoxazolo-, pyrimido- and mercaptopyrimidocyclohepta[b]indoles

Exotines A and B, Two Heterodimers of Isopentenyl-Substituted Indole and Coumarin Derivatives from Murraya exotica

“…Finally, the absolute configuration There were numerous articles about the isolation and synthesis of tetrahydrocyclohepta[b]indole derivatives, 18−20 and their various pharmacological properties such as the inhibition of deacetylase SIRT121 and antitubercular activity. 22 Yet, such unusual heterodimers of isopentenyl-substitued indole and coumarin derivatives, linked through a new fused heptacyclic ring skeleton, have never been reported. A plausible biogenetic pathway to exotines A (1) and B (2) was proposed via a hetero-Diels−Alder cycloaddition as illustrated in Scheme 1, using 3-prenylindole and trans-dehydroosthol derivatives, which had been isolated from Murraya species, 23−25 as the precursors.…”

Magnetically separable sulfonic acid catalysed one-pot synthesis of diverse indole derivatives

“…2 Use of magnetically separable and reusable catalyst in a solvent-free multicomponent reaction fulfils multiple green synthesis requirements such as use of recyclable catalyst, employing less hazardous solvent, achieving high atom economy, reducing the number of reaction steps etc. Use of aforementioned conditions in substituted indole synthesis is desirable since indole derivatives possess antiviral, 3 anti-HIV, 4 anti-cancer, 5 antiproliferative, 6 antibacterial, 7 cytotoxic, 8 antitubercular 9 and antiinflammatory activities (Fig. 1).…”

Synthesis of alpha amylase inhibitors based on privileged indole scaffold

“…The biological importance of indole heterocycles and their pharmacological and medical potential had made them extremely attractive and rewarding research targets and these qualities have motivated countless researchers to study their synthesis and pharmacological properties [14]. The biological activities of indoles cover a wide spectrum, including anticancer [15], antibacterial and antimicrobial [16], anti-inflammatory [17], antimalarial and cytotoxic [18] and antitubercular [19] activities. We found that few natural products having indole moiety showed good activity [20][21][22], which excited us to design and synthesize cost effective indole derivatives for α-amylase inhibitory potential.…”