Synthesis, Antimicrobial, and DFT Studies of Some Benzyl 4-O-Acyl-α-L-rhamnopyranosides

Muhammad, Deen; Matin, Mohammed Mahbubul; Miah, Sheikh Md. Rasel; Devi, Puja

doi:10.17807/orbital.v13i3.1614

Cited by 11 publications

(8 citation statements)

References 1 publication

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“…The antibacterial activities were studied using the agar diffusion method [29]. The nutrient agar was prepared as per the following composition: peptones 0.5 % (concentration), yeast extract 0.3 %, sodium chloride 0.5 %, agar 1.5 %, pH 5.6 ±0.2, distilled water 1000 mL.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Enhanced Anticarcinogenic and Antimicrobial Response of Synthesized Tungsten Oxide Nanoparticles

Kumari

Mangala

2023

J. Sci. Res.

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In the present study, we fabricated tungsten trioxide nanoparticles (WO3 NPs) from a tungsten complex [W(C13H10NO)3] of ligand N-salicylideneaniline with tungstic acid as the precursor. Nanoparticles were synthesized using the direct thermal decomposition method. These nanoparticles were evaluated for cytotoxicity influence on human breast cancer MCF7 cell line (adenocarcinoma). The observed results suggested that WO3 can destroy 50 % of viable cells after 24 h of incubation at 37 °C. Based on these results, we concluded that WO3 nanoparticles could be a potential drug carrier candidate against human breast cancer cells based on the amount of the drug. In addition, WO3 nanoparticles exhibited significant antimicrobial and antifungal activity.

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Section: Antibacterial Activitymentioning

confidence: 99%

Enhanced Anticarcinogenic and Antimicrobial Response of Synthesized Tungsten Oxide Nanoparticles

Kumari

Mangala

2023

J. Sci. Res.

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“…Finally, molecular orbitals of 4-8a-e in the forms of HOMO (highest occupied molecular orbital) and LUMO (lowest unoccupied molecular orbital) energy levels, their gaps (Δε) hardness, softness, and dipole moments (DM) are calculated from their optimized structures (Muhammad et al, 2021). These results as presented in Table 3 indicated that acetonide-protected compound 5 (C, TB, and B forms) possess slightly lower Δε than the non-acetonide compounds 4, 7, and 8a-e. Incorporation of pivaloyl groups at C-4 positions of 5, as in 6, slightly increased Δε value.…”

Section: Molecular Orbital Analysismentioning

confidence: 99%

SYNTHESIS, CHARACTERIZATION, IN SILICO OPTIMIZATION, AND CONFORMATIONAL STUDIES OF METHYL 4-O-Pivaloyl-Α-L-Rhamnopyranosides

Matin

Postdoc²,

Ibrahim

et al. 2022

MJS

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Considering promising biological activities of natural and synthetic rhamnopyranoside esters, we have synthesized several methyl 4-O-pivaloyl-α-L-rhamnopyranosides via selective 2,3-O-acetonide protection of methyl α-L-rhamnopyranoside (4) followed by C-4 pivaloylation, and deprotection. The synthesized 4-O-pivaloate 7 and its 2,3-di-O-esters 8a-e are characterized by spectroscopy and are optimized by using density functional theory (DFT). The free energy and bond angles thus calculated are used to establish the probable conformation(s). The 2,3-O-acetonide protected rhamnopyranosides 5-6 are found to be slightly distorted from the regular 1C4 conformation, and exist between the chair and twist-boat (skew) conformation while other pivaloyl esters 7-8a-e exist in regular 1C4 chair conformation.

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“…The antibacterial activities were analysed by the agar diffusion method [36]. The nutrient agar was prepared as per the following composition: peptones 0.5% (concentration), yeast extract 0.3 %, sodium chloride 0.5 %, agar 1.5 %, pH 5.6 ± 0.2, distilled water 1000 mL.…”

Section: Antibacterial Activity Experimentsmentioning

confidence: 99%

Fabrication and Characterization of Molybdenum Trioxide Nanoparticles and their Anticancer, Antibacterial and Antifungal Activities

2022

MJCHEM

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The present study focused on the fabrication of molybdenum trioxide nanoparticles (MoO3) from a molybdenum complex with N-salicylideneaniline [Mo(C13H10NO)3] ligand as the precursor. The ligand was synthesized and characterized by 1 H NMR and 13 C NMR. The synthesized MoO3 nanoparticles were characterized by powder X-ray diffraction, FT-IR, UV-visible spectroscopy, TG-DTA, SEM-EDX and TEM. The results clearly showed the formation of nanoparticles of MoO3. The absorption spectra of MoO3 at 341 nm revealed the formation of MoO3 by calculating the band gap at 2.8 eV. TG-DTA showed MoO3 was stable up to 800 °C. SEM and TEM analyses clearly indicated the formation of MoO3 nanoparticles in the range of 30-47 nm. The NPs were tested for their cytotoxicity influence on MCF7-human breast adenocarcinoma cell lines. The findings suggested MoO3 had the capacity to kill 50% of viable cells after 24 h of incubation at 37 °C. The observations strongly suggest that MoO3 nanoparticles have therapeutic potential against human breast cancer cells based on the dosage of the drug after an incubation period of 24 h.

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Synthesis, Antimicrobial, and DFT Studies of Some Benzyl 4-O-Acyl-α-L-rhamnopyranosides

Cited by 11 publications

References 1 publication

Enhanced Anticarcinogenic and Antimicrobial Response of Synthesized Tungsten Oxide Nanoparticles

Enhanced Anticarcinogenic and Antimicrobial Response of Synthesized Tungsten Oxide Nanoparticles

SYNTHESIS, CHARACTERIZATION, IN SILICO OPTIMIZATION, AND CONFORMATIONAL STUDIES OF METHYL 4-O-Pivaloyl-Α-L-Rhamnopyranosides

Fabrication and Characterization of Molybdenum Trioxide Nanoparticles and their Anticancer, Antibacterial and Antifungal Activities

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