Synthesis, antimicrobial and anti-inflammatory activities of novel 5-(1-adamantyl)-1,3,4-thiadiazole derivatives

Crystal structure of 1-(adamantan-1-yl)-3-(3-chlorophenyl)thiourea, C17H21ClN2S

“…As a part of our current research interest in the chemotherapeutic properties of adamantane derivatives [17][18][19] and the molecular structural of adamantyl thiourea analogues [20][21][22], we report herein the synthesis and crystal title structure. The asymmetric unit cell of the title structure contains two independent molecules.…”

Crystal structure of 4-bromobenzyl (Z)-N′-(adamantan-1-yl)-4-phenylpiperazine-1-carbothioimidate, C28H34BrN3S

“…Several adamantane-based drugs are currently used as useful medications for the control of central nervous disorders [10][11][12][13]. In addition, potent antimicrobial [14][15][16], anticancer [17,18], anti-in ammatory [19][20][21] and hypoglycemic [22] activities were reported for numerous adamantane-based derivatives. Isothiourea derivatives were also recognized as a structural motif of particular value in medicinal chemistry possessing diverse biological activities [23,24].…”

Crystal structure of 1-(adamantan-1-yl)-3-(4-bromophenyl)thiourea, C17H21BrN2S

“…In addition, thiourea derivatives were reported to display marked antitumor [13], anti-HIV [14], antimalarial [15] and antimicrobial [16] activities. As a part of our current research interest in the pharmacological [17][18][19] and structural [20][21][22] properties of adamantane derivatives, we report herein the synthesis and crystal structure of the title compound as bioactive agent and as precursor for adamantanebased chemotherapeutic agents. The asymmetric unit of the title structure contains one independent molecule.…”