Synthesis, antimicrobial, and anti-HIV-1 activity of certain 5-(1-adamantyl)-2-substituted thio-1,3,4-oxadiazoles and 5-(1-adamantyl)-3-substituted aminomethyl-1,3,4-oxadiazoline-2-thiones

Crystal structure of 1-(adamantan-1-yl)-3-(4-bromophenyl)thiourea, C17H21BrN2S

“…In addition, thiourea derivatives were reported to display marked antitumor [13], anti-HIV [14], antimalarial [15] and antimicrobial [16] activities. As a part of our current research interest in the pharmacological [17][18][19] and structural [20][21][22] properties of adamantane derivatives, we report herein the synthesis and crystal structure of the title compound as bioactive agent and as precursor for adamantanebased chemotherapeutic agents. The asymmetric unit of the title structure contains one independent molecule.…”

Crystal structure of 5-(adamantan-1-yl)-3-[(4-chloroanilino)methyl]-2,3-dihydro-1,3,4-oxadiazole-2-thione, C19H22ClN3OS

“…Several adamantane derivatives are currently used as e cient therapies against in uenza [3][4][5], herpes simplex [6] and HIV [7][8][9] viruses. In addition, numerous adamantane derivatives were reported to exhibit marked anticancer [10,11], antibacterial [12][13][14][15] and antifungal [16] activities.…”

“…In addition, numerous adamantane derivatives were reported to exhibit marked anticancer [10,11], antibacterial [12][13][14][15] and antifungal [16] activities. In continuation to our ongoing interest in the chemical and biological properties of adamantane derivatives, we report herein the crystal structure of the title compound which displayed potent broad spectrum antibacterial activity [9]. The title compound is a functionalized 1,3,4-oxadiazole-2-thione derivative.…”

“…M.p. 450-452 K [9]. Colourless prismatic single crystals were obtained by slow evaporation of chloroform-ethanol solution (1:1) at room temperature.…”

Crystal structure of 1-(adamantan-1-yl)-3-phenylthiourea, C17H22N2S

“…In addition, thiourea derivatives are recognized as potent anti-Malaria [11], anti-HIV [12], anticancer [13] and antimicrobial [14] agents. As a part of an ongoing research interest in the chemotherapeutic [15][16][17] and structure [18][19][20] of adamantane derivatives, we report herein, the crystal structural of the title compound. In the title structure the asymmetric unit of the crystal structure contains one molecule.…”